Evidence map›Paper›PMID 22449039›Full record

ReviewThe Plant journal : for cell and molecular biology2012

Cell type-specific transcriptional profiling: implications for metabolite profiling.

Eric D Rogers, Terry Jackson, Arieh Moussaieff, Asaph Aharoni, Philip N Benfey

Abstract readReview
In one paragraph

Review in The Plant journal : for cell and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
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  11. Article
  12. Review
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  15. Article
  16. High-resolution metabolic mapping of cell types in plant roots.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  17. Article
  18. Catalyzing plant science research with RNA-seq.Frontiers in plant science · 2013
    Article
  19. Technologies for systems-level analysis of specific cell types in plants.Plant science : an international journal of experimental plant biology · 2012
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eric D RogersDepartment of Biology and Duke Center for Systems Biology, Duke University, Durham, NC 27708, USA.
Terry Jackson
Arieh Moussaieff
Asaph Aharoni
Philip N Benfey

Funding

Project 6P50GM081883 · NIGMS · DUKE UNIVERSITY · PI BENFEY, PHILIP N · 2007 to 2012
$14.9M
NIGMS NIH HHS P50 GM081883
6 · The paper itself

Abstract

Plant development and survival is centered on complex regulatory networks composed of genes, proteins, hormone pathways, metabolites and signaling pathways. The recent advancements in whole genome biology have furthered our understanding of the interactions between these networks. As a result, numerous cell type-specific transcriptome profiles have been generated that have elucidated complex gene regulatory networks occurring at the cellular level, many of which were masked during whole-organ analysis. Modern technologies have also allowed researchers to generate multiple whole-organ metabolite profiles; however, only a limited number have been generated at the level of individual cells. Recent advancements in the isolation of individual cell populations have made cell type-specific metabolite profiles possible, enabling the enhanced detection and quantification of metabolites that were formerly unavailable when considering the whole organ. The comparison of metabolite and transcriptome profiles from the same cells has been a valuable resource to generate predictions regarding specific metabolite activity and function. In this review, we focus on recent studies that demonstrate the value of cell type-specific transcriptional profiles and their comparison with profiles generated from whole organs. Advancements in the isolation of single-cell populations will be highlighted, and the potential application towards generating detailed metabolic profiles will be discussed.

Indexed as

Gene Expression ProfilingMetabolomicsFlow CytometryGene Regulatory NetworksLaser Capture MicrodissectionMeristemPlant RootsPlantsPlant Shoots

Identifiers

PMID22449039
PMCPMC3315153

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.