ArticlePulmonary medicine2012
Combined Pulmonary Fibrosis and Emphysema Syndrome: A New Phenotype within the Spectrum of Smoking-Related Interstitial Lung Disease.
Article in Pulmonary medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Lung Cancer in Combined Pulmonary Fibrosis and Emphysema: A Systematic Review and Meta-Analysis.PloS one · 2016Pooled it
- Combined pulmonary fibrosis and emphysema: a narrative review.Frontiers in medicine · 2025Review
- Review
- [Smoking-related interstitial lung diseases].Radiologie (Heidelberg, Germany) · 2022Review
- Differential Genomic Profile inFrontiers in medicine · 2021Article
- Combined pulmonary fibrosis and emphysema characteristics in a Greek cohort.ERJ open research · 2019Article
- Improvement of pulmonary arterial compliance by pulmonary vasodilator in pulmonary hypertension from combined pulmonary fibrosis and emphysema.Respiratory medicine case reports · 2019Article
- Clinical characteristics and outcomes of lung cancer patients with combined pulmonary fibrosis and emphysema: a systematic review and meta-analysis of 13 studies.Journal of thoracic disease · 2017Article
- Combined pulmonary fibrosis and emphysema (CPFE): what radiologist should know.La Radiologia medica · 2016Review
- Images in COPD: Combined Pulmonary Fibrosis and Emphysema.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2015Article
- Prevalence and progression of combined pulmonary fibrosis and emphysema in asymptomatic smokers: A case-control study.European radiology · 2015Article
- FDG PET imaging for identifying pulmonary hypertension and right heart failure.Current cardiology reports · 2015Review
- Smoking-related idiopathic interstitial pneumonia.The European respiratory journal · 2014Article
- Idiopathic pulmonary fibrosis as a prognostic factor in non-small cell lung cancer.International journal of clinical oncology · 2014Article
- The impact of emphysema in pulmonary fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2013Review
- Combined Pulmonary Fibrosis and Emphysema (CPFE) Clinical Features and Management.International journal of chronic obstructive pulmonary diseaseReview
- Electron Microscopic Analysis of Silicate and Calcium Particles in Cigarette Smoke Tar.International journal of respiratory and pulmonary medicineArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combined pulmonary fibrosis and emphysema (CPFE) is a recently defined syndrome, in which centrilobular and/or paraseptal emphysemas in upper lung zones coexist with pulmonary fibrosis in lower lobes in individuals. These patients have a characteristic lung function profile, with unexpected subnormal dynamic and static lung volumes, contrasting with a significant reduction of carbon monoxide transfer (DL(co)) and exercise hypoxemia. Pulmonary hypertension is highly prevalent in CPFE and is the leading determinant of death. Tobacco smoking has been proposed as the main factor in its etiology, though the pathophysiology and its natural history remain to be determined. High-resolution computed axial tomography is the mandatory tool to confirm the diagnosis. Currently, there is no consensus about its treatment since those published to date on this issue are limited to well-characterised series of cases; hence, a better understanding of this entity may help in the development of future therapeutic approaches.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.