ArticleInternational journal of preventive medicine2012
Should We Look for Celiac Disease among all Patients with Liver Function Test Abnormalities?
Article in International journal of preventive medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Celiac Disease With Autoimmune Hemolytic Anemia and Autoimmune Hepatitis in a Young Child: Case Report and Literature Review.Clinical medicine insights. Pediatrics · 2022Article
- Discordance Between Serology and Histology for Celiac Disease in a Cohort with Coexisting Liver Disorders.Journal of the Canadian Association of Gastroenterology · 2020Article
- Gluten-free products in celiac disease: Nutritional and technological challenges and solutions.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Review
- Prevalence of Celiac Disease in Children with Autoimmune Hepatitis and vice versa.Iranian journal of pediatrics · 2014Article
- The effect of Helicobacter pylori eradication on liver enzymes in patients referring with unexplained hypertransaminasemia.Advanced biomedical research · 2014Article
- The effects of gluten-free diet on hypertransaminasemia in patients with celiac disease.International journal of preventive medicine · 2013Article
- Celiac disease and abnormal liver function test.International journal of preventive medicine · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCeliac disease (CD) has been found in up to 10% of the patients presenting with unexplained abnormal liver function tests (LFT). As there is no precise data from our country in this regard, we investigated the prevalence of CD in patients presenting with abnormal LFT.
methodsFrom 2003 to 2008, we measured IgA anti-tissue transglutaminase (t-TG) antibody (with ELISA technique) within the first-level screening steps for all patients presenting with abnormal LFT to three outpatient gastroenterology clinics in Isfahan, IRAN. All subjects with an IgA anti-tTG antibody value of >10 μ/ml (seropositive) were undergone upper gastrointestinal endoscopy and duodenal biopsy. Histopathological changes were assessed according to the Marsh classification. CD was defined as being seropositive with Marsh I or above in histopathology and having a good response to gluten free diet (GFD).
resultsDuring the study, 224 patients were evaluated, out of which, 10 patients (4.4%) were seropositive for CD. Duodenal biopsies were performed in eight patients and revealed six (2.7%) cases of Marsh I or above (four Marsh IIIA, two Marsh I), all of them had good response to GFD. The overall prevalence of CD among patients with hypertransaminasemia, autoimmune hepatitis, and cryptogenic cirrhosis was determined as 10.7% (3/28), 3.4% (2/59), and 5.3% (1/19), respectively.
conclusionSerological screening with IgA anti-tTG antibody test should be routinely performed in patients presenting with abnormal LFT and especially those with chronic liver diseases including hypertransaminasemia, autoimmune hepatitis, and cryptogenic cirrhosis.
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Identifiers
22448309PMC3309630W2118691100What OpenQuestion holds
Registered trials
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