ArticlePloS one2012
Phosphatidylinositol 3-kinase plays a vital role in regulation of rice seed vigor via altering NADPH oxidase activity.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 63 citations in OpenAlex.
- OsMYB94 functions as a master regulator of metabolic pathways associated with rice caryopsis maturation and quality formation.The New phytologist · 2026Article
- Knockout of OsRbohD (the NADPH Oxidase Gene) Enhances Saline-Alkaline Stress Tolerance and Grain Yield in Rice by Reducing ROS Accumulation.Rice (New York, N.Y.) · 2026Article
- Fulvic Acid Suppresses Excessive Cytokinin Biosynthesis to Reduce ROS Content and thus Decrease NaRice (New York, N.Y.) · 2026Article
- Adaptive dynamics of extrachromosomal circular DNA in rice under nutrient stress.Nature communications · 2025Article
- CRISPR/Cas knockout of the NADPH oxidase gene OsRbohB reduces ROS overaccumulation and enhances heat stress tolerance in rice.Plant biotechnology journal · 2025Article
- Simultaneous improvement and genetic dissection of drought and submergence tolerances in rice (Frontiers in plant science · 2023Article
- ThSCSP_12: Novel Effector inInternational journal of molecular sciences · 2022Article
- Raffinose family oligosaccharides (RFOs): role in seed vigor and longevity.Bioscience reports · 2022Review
- Characteristics of Seed Vigor in Rice Varieties with Different Globulin Accumulations.International journal of molecular sciences · 2022Article
- Investigation of the Genotoxic, Cytotoxic, Apoptotic, and Oxidant Effects of Olive Leaf Extracts on Liver Cancer Cell Lines.Turkish journal of pharmaceutical sciences · 2021Article
- Phospholipids in Salt Stress Response.Plants (Basel, Switzerland) · 2021Review
- LPIAT, aInternational journal of molecular sciences · 2020Article
- Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies-Activities Against Blood StageFrontiers in chemistry · 2019Article
- A Snapshot of the Trehalose Pathway During Seed Imbibition inFrontiers in plant science · 2019Article
- Phosphoinositide 3-Kinase Promotes Oxidative Burst, Stomatal Closure and Plant Immunity in Bacterial Invasion.Frontiers in plant science · 2019Article
- Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages.Antimicrobial agents and chemotherapy · 2018Article
- Transcriptional regulatory network of WOX11 is involved in the control of crown root development, cytokinin signals, and redox in rice.Journal of experimental botany · 2017Article
- Genetic Modification for Improving Seed Vigor Is Transitioning from Model Plants to Crop Plants.Frontiers in plant science · 2017Article
- A pivotal role of phosphatidylinositol 3-kinase in delaying of methyl jasmonate-induced leaf senescence.Plant signaling & behavior · 2016Article
- Phosphatidylinositol 3-Kinase Promotes Activation and Vacuolar Acidification and Delays Methyl Jasmonate-Induced Leaf Senescence.Plant physiology · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphatidylinositol 3-kinase (PI3K) has been reported to be important in normal plant growth and stress responses. In this study, it was verified that PI3K played a vital role in rice seed germination through regulating NADPH oxidase activity. Suppression of PI3K activity by inhibitors wortmannin or LY294002 could abate the reactive oxygen species (ROS) formation, which resulted in disturbance to the seed germination. And then, the signal cascades that PI3K promoted the ROS liberation was also evaluated. Diphenylene iodonium (DPI), an NADPH oxidase inhibitor, suppressed most of ROS generation in rice seed germination, which suggested that NADPH oxidase was the main source of ROS in this process. Pharmacological experiment and RT-PCR demonstrated that PI3K promoted the expression of Os rboh9. Moreover, functional analysis by native PAGE and the measurement of the 2, 3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazo-lium-5- carboxanilide (XTT) formazan concentration both showed that PI3K promoted the activity of NADPH oxidase. Furthermore, the western blot analysis of OsRac-1 demonstrated that the translocation of Rac-1 from cytoplasm to plasma membrane, which was known as a key factor in the assembly of NADPH oxidase, was suppressed by treatment with PI3K inhibitors, resulting in the decreased activity of NADPH oxidase. Taken together, these data favored the novel conclusion that PI3K regulated NADPH oxidase activity through modulating the recruitment of Rac-1 to plasma membrane and accelerated the process of rice seed germination.
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