ArticlePloS one2012
Assessment of gastroenteric viruses frequency in a children's day care center in Rio De Janeiro, Brazil: a fifteen year study (1994-2008).
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Prevalence and Genetic Diversity of Norovirus in Acute Gastroenteritis Cases in the Southwest Province of Turkey.Balkan medical journal · 2022Article
- Human astrovirus types 1, 4 and 5 circulating among children with acute gastroenteritis in a rural Brazilian state, 2010-2016.Archives of virology · 2021Article
- Single-step RT-PCR assay for dual genotyping of GI and GII norovirus strains.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2021Article
- Nearly complete genome sequence of one GII.17 Norovirus identified by direct sequencing from HuZhou, China.Molecular genetics & genomic medicine · 2018Article
- Circulating rotavirus G and P strains post rotavirus vaccination in Eastern Mediterranean Region.Saudi medical journal · 2018Review
- Surveillance of Noroviruses in Rio De Janeiro, Brazil: Occurrence of New GIV Genotype in Clinical and Wastewater Samples.Food and environmental virology · 2018Article
- Article
- Clinical and molecular analyses of norovirus-associated sporadic acute gastroenteritis: the emergence of GII.17 over GII.4, Huzhou, China, 2015.BMC infectious diseases · 2016Article
- A non-enteric adenovirus A12 gastroenteritis outbreak in Rio de Janeiro, Brazil.Memorias do Instituto Oswaldo Cruz · 2016Article
- Norovirus Recombinant Strains Isolated from Gastroenteritis Outbreaks in Southern Brazil, 2004-2011.PloS one · 2016Article
- A novel norovirus GII.17 lineage contributed to adult gastroenteritis in Shanghai, China, during the winter of 2014–2015.Emerging microbes & infections · 2015Article
- Emergence and predominance of norovirus GII.17 in Huzhou, China, 2014-2015.Virology journal · 2015Article
- Wastewater Analysis Indicates that Genetically Diverse Astroviruses, Including Strains Belonging to Novel Clades MLB and VA, Are Circulating within Japanese Populations.Applied and environmental microbiology · 2015Article
- Emergence of a novel GII.17 norovirus – End of the GII.4 era?Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2015Article
- Effect of monovalent rotavirus vaccine on rotavirus disease burden and circulating rotavirus strains among children in Morocco.Journal of medical virology · 2015Article
- The prevalence of norovirus, astrovirus and adenovirus infections among hospitalised children with acute gastroenteritis in Porto Velho, state of Rondônia, western Brazilian Amazon.Memorias do Instituto Oswaldo Cruz · 2015Article
- Environmental Assessment of Classical Human Astrovirus in Uruguay.Food and environmental virology · 2015Article
- Surveillance of Human Astrovirus Infection in Brazil: The First Report of MLB1 Astrovirus.PloS one · 2015Article
- Norovirus GII.17 Predominates in Selected Surface Water Sources in Kenya.Food and environmental virology · 2014Article
- Epidemiological and molecular features of norovirus infections in Italian children affected with acute gastroenteritis.Epidemiology and infection · 2014Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This 15-year study aimed to determine the role of the main viruses responsible for acute infantile gastroenteritis cases in a day care center in the city of Rio de Janeiro, Brazil. From 1994 to 2008, 539 fecal samples were obtained from 23 outbreaks as well as sporadic cases that occurred in this period. The detection of Rotavirus group A (RVA), norovirus (NoV) and astrovirus (AstV) was investigated both by classical and molecular methods of viral detection. RVA was detected by enzymatic immune assay and/or polyacrylamide gel electrophoresis and genotyped by using semi-nested multiplex PCR. NoV and AstV were subsequently tested by real time PCR in all RVA-negative samples and genotyped throughout genome sequencing. Three protocols for molecular characterization of NoV nucleotide sequencing were performed with the partial nucleotide sequencing of genomic regions known as region B (polymerase gen), C and D (capsid gen).Viruses were identified in 47.7% (257/539) of the cases, and the detection rates of RVA, NoV and AstV in16.1% (87/539), 33.4% (151/452), and 6.3% (19/301), respectively. Most gastroenteritis cases were reported in autumn and winter, although NoV presented a broader monthly distribution. Viruses' detection rates were significantly higher among children aged less than 24 months old, although NoV cases were detected in all age groups. RVA genotypes as G1P[8], G9P[8], G2P[4], G3P[8] and G1+G3P[8] and RVA was no longer detected after 2005. NoV characterization revealed genotypes variability circulating in the period as GI.2, GI.3, GI.8 GII.2, GII.3, GII.4, GII.4 variants 2001 and 2006b, GII.6, GII.7, GII.12 and GII.17. AstV genotypes 1, 2, 4 and 5 were also characterized. Those data demonstrate the impact of NoV infection in cases of infantile gastroenteritis, surpassing RVA infection responsible for high morbidity rate in children under five years old.
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