ArticlePloS one2012
Role of trehalose in salinity and temperature tolerance in the model halophilic bacterium Chromohalobacter salexigens.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Effects of sublethal stress application on the survival of bacterial inoculants: a systematic review.Archives of microbiology · 2023Pooled it
- Functional and genomic characterization of halotolerant Bacillus paramycoides MSR1 for MICCP-based durability enhancement of cementitious materials under saline conditions.World journal of microbiology & biotechnology · 2026Article
- Halophilic bacteria and archaea in salinity-resilient agriculture: mechanisms and multi-omics perspectives.Archives of microbiology · 2026Review
- Cross-domain transfer of trehalose biosynthesis genes contributes to adaptation in high-altitude environments.National science review · 2026Article
- Putative membrane protein Cgl2168 and its variant enhance thermotolerance inSynthetic and systems biotechnology · 2026Article
- Synergistic effects of sequential light treatment with 222-nm/405-nm and 280-nm/405-nm wavelengths on inactivation of foodborne pathogens.Applied and environmental microbiology · 2023Article
- A Novel Glycoside Hydrolase DogH Utilizing Soluble Starch to Maltose Improve Osmotic Tolerance inInternational journal of molecular sciences · 2023Article
- Article
- Role of carnitine in adaptation of Chromohalobacter salexigens DSM 3043 and its mutants to osmotic and temperature stress in defined medium.Extremophiles : life under extreme conditions · 2022Article
- Unraveling potential enzymes and their functional role in fine cocoa beans fermentation using temporal shotgun metagenomics.Frontiers in microbiology · 2022Article
- New insights into hydroxyectoine synthesis and its transcriptional regulation in the broad-salt growing halophilic bacterium Chromohalobacter salexigens.Microbial biotechnology · 2021Article
- Trehalose and α-glucan mediate distinct abiotic stress responses in Pseudomonas aeruginosa.PLoS genetics · 2021Article
- Choosing source of microorganisms and processing technology for next generation beet bioinoculant.Scientific reports · 2021Article
- Genome-centric resolution of novel microbial lineages in an excavated Centrosaurus dinosaur fossil bone from the Late Cretaceous of North America.Environmental microbiome · 2020Article
- Genome Insights of the Plant-Growth Promoting BacteriumFrontiers in microbiology · 2020Article
- Streptomyces albulus yields ε-poly-L-lysine and other products from salt-contaminated glycerol waste.Journal of industrial microbiology & biotechnology · 2018Article
- Genome-based classification of micromonosporae with a focus on their biotechnological and ecological potential.Scientific reports · 2018Article
- Establishment of a markerless gene deletion system in Chromohalobacter salexigens DSM 3043.Extremophiles : life under extreme conditions · 2017Article
- Article
- Draft genome sequences of strainsStandards in genomic sciences · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The disaccharide trehalose is considered as a universal stress molecule, protecting cells and biomolecules from injuries imposed by high osmolarity, heat, oxidation, desiccation and freezing. Chromohalobacter salexigens is a halophilic and extremely halotolerant γ-proteobacterium of the family Halomonadaceae. In this work, we have investigated the role of trehalose as a protectant against salinity, temperature and desiccation in C. salexigens. A mutant deficient in the trehalose-6-phosphate synthase gene (otsA::Ω) was not affected in its salt or heat tolerance, but double mutants ectoine- and trehalose-deficient, or hydroxyectoine-reduced and trehalose-deficient, displayed an osmo- and thermosensitive phenotype, respectively. This suggests a role of trehalose as a secondary solute involved in osmo- (at least at low salinity) and thermoprotection of C. salexigens. Interestingly, trehalose synthesis was osmoregulated at the transcriptional level, and thermoregulated at the post-transcriptional level, suggesting that C. salexigens cells need to be pre-conditioned by osmotic stress, in order to be able to quickly synthesize trehalose in response to heat stress. C. salexigens was more sensitive to desiccation than E. coli and desiccation tolerance was slightly improved when cells were grown at high temperature. Under these conditions, single mutants affected in the synthesis of trehalose or hydroxyectoine were more sensitive to desiccation than the wild-type strain. However, given the low survival rates of the wild type, the involvement of trehalose and hydroxyectoine in C. salexigens response to desiccation could not be firmly established.
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