ArticlePloS one2012
Involvement of Wnt signaling pathways in the metamorphosis of the bryozoan Bugula neritina.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- Differential Gene Expression Between Polymorphic Zooids of the Marine BryozoanG3 (Bethesda, Md.) · 2020Article
- Differential gene expression during substrate probing in larvae of the Caribbean coral Porites astreoides.Molecular ecology · 2019Article
- A novel assessment of the traction forces upon settlement of two typical marine fouling invertebrates using PDMS micropost arrays.Biology open · 2018Article
- Locus Mapping, Molecular Cloning, and Expression Analysis of rps6kb2, a Novel Metamorphosis-Related Gene in Chinese Tongue Sole (Cynoglossus semilaevis).Marine biotechnology (New York, N.Y.) · 2017Article
- The transcriptome of metamorphosing flatfish.BMC genomics · 2016Article
- Transcriptome Characterization of Dendrolimus punctatus and Expression Profiles at Different Developmental Stages.PloS one · 2016Article
- Transcriptome analysis elucidates key developmental components of bryozoan lophophore development.Scientific reports · 2014Article
- Post-embryonic transcriptomes of the prawn Macrobrachium rosenbergii: multigenic succession through metamorphosis.PloS one · 2013Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we analyzed the metamorphosis of the marine bryozoan Bugula neritina. We observed the morphogenesis of the ancestrula. We defined three distinct pre-ancestrula stages based on the anatomy of the developing polypide and the overall morphology of pre-ancestrula. We then used an annotation based enrichment analysis tool to analyze the B. neritina transcriptome and identified over-representation of genes related to Wnt signaling pathways, suggesting its involvement in metamorphosis. Finally, we studied the temporal-spatial gene expression studies of several Wnt pathway genes. We found that one of the Wnt ligand, BnWnt10, was expressed spatially opposite to the Wnt antagonist BnsFRP within the blastemas, which is the presumptive polypide. Down-stream components of the canonical Wnt signaling pathway were exclusively expressed in the blastemas. Bnβcatenin and BnFz5/8 were exclusively expressed in the blastemas throughout the metamorphosis. Based on the genes expression patterns, we propose that BnWnt10 and BnsFRP may relate to the patterning of the polypide, in which the two genes served as positional signals and contributed to the polarization of the blastemas. Another Wnt ligand, BnWnt6, was expressed in the apical part of the pre-ancestrula epidermis. Overall, our findings suggest that the Wnt signaling pathway may be important to the pattern formation of polypide and the development of epidermis.
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