ArticlePloS one2012
Discovery of defense- and neuropeptides in social ants by genome-mining.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 69 citations in OpenAlex.
- Article
- Conserved and differing functions of the endocrine system across different social systems - oxytocin as a case study.Frontiers in endocrinology · 2024Review
- Bioactive Molecules from the Innate Immunity of Ascidians and Innovative Methods of Drug Discovery: A Computational Approach Based on Artificial Intelligence.Marine drugs · 2023Review
- Whole Genome Duplication and Gene Evolution in the Hyperdiverse Venomous Gastropods.Molecular biology and evolution · 2023Article
- Multiplexed neuropeptide mapping in ant brains integrating microtomography and three-dimensional mass spectrometry imaging.PNAS nexus · 2023Article
- An oxytocin/vasopressin-related neuropeptide modulates social foraging behavior in the clonal raider ant.PLoS biology · 2021Article
- Trends in peptide drug discovery.Nature reviews. Drug discovery · 2021Article
- Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin.Chemical science · 2021Article
- Genome Mining-Based Discovery of Blenny Fish-Derived Peptides Targeting the Mouse κ-Opioid Receptor.Frontiers in pharmacology · 2021Article
- Isolation of Cysteine-Rich Peptides fromBiomolecules · 2020Article
- Review
- Genome Mining as New Challenge in Natural Products Discovery.Marine drugs · 2020Review
- Comparative and Evolutionary Physiology of Vasopressin/ Oxytocin-Type Neuropeptide Signaling in Invertebrates.Frontiers in endocrinology · 2020Review
- Oxytocin/vasopressin-like neuropeptide signaling in insects.Vitamins and hormones · 2020Review
- Genome-wide analysis reveals the genomic features of the turkey vulture (Cathartes aura) as a scavenger.Molecular genetics and genomics : MGG · 2019Article
- Oxytocin/vasopressin-like peptide inotocin regulates cuticular hydrocarbon synthesis and water balancing in ants.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Discovery of peptide probes to modulate oxytocin-type receptors of insects.Scientific reports · 2018Article
- Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species.Science signaling · 2017Article
- Development of a human vasopressin VScientific reports · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Natural peptides of great number and diversity occur in all organisms, but analyzing their peptidome is often difficult. With natural product drug discovery in mind, we devised a genome-mining approach to identify defense- and neuropeptides in the genomes of social ants from Atta cephalotes (leaf-cutter ant), Camponotus floridanus (carpenter ant) and Harpegnathos saltator (basal genus). Numerous peptide-encoding genes of defense peptides, in particular defensins, and neuropeptides or regulatory peptide hormones, such as allatostatins and tachykinins, were identified and analyzed. Most interestingly we annotated genes that encode oxytocin/vasopressin-related peptides (inotocins) and their putative receptors. This is the first piece of evidence for the existence of this nonapeptide hormone system in ants (Formicidae) and supports recent findings in Tribolium castaneum (red flour beetle) and Nasonia vitripennis (parasitoid wasp), and therefore its confinement to some basal holometabolous insects. By contrast, the absence of the inotocin hormone system in Apis mellifera (honeybee), another closely-related member of the eusocial Hymenoptera clade, establishes the basis for future studies on the molecular evolution and physiological function of oxytocin/vasopressin-related peptides (vasotocin nonapeptide family) and their receptors in social insects. Particularly the identification of ant inotocin and defensin peptide sequences will provide a basis for future pharmacological characterization in the quest for potent and selective lead compounds of therapeutic value.
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Registered trials
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