ArticlePloS one2012
Layer-specific fMRI reflects different neuronal computations at different depths in human V1.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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Who cites it
112 citing papers in PubMed.
- Trial
- Whole-brain three-dimensional T2-weighted BOLD functional magnetic resonance imaging at 7 Tesla.Magnetic resonance in medicine · 2014Trial
- Cortical depth dependent functional responses in humans at 7T: improved specificity with 3D GRASE.PloS one · 2013Trial
- Temporal kinetics of brain state effects on visual perception.Scientific reports · 2026Article
- Bridging the gap with invasive imaging: promises and challenges of a new generation of ultrahigh resolution fMRI.bioRxiv : the preprint server for biology · 2026Article
- Comprehensive 4D Parallel Transmission Spatial-Spectral Pulse Design for Slab-Selective Uniform Water-Selective Excitation: Demonstration in the Human Brain at 7 Tesla.Magnetic resonance in medicine · 2026Article
- Impact of thermal and physiological denoising on laminar functional connectivity.Scientific reports · 2026Article
- Visual cortex speckle imaging for shape recognition.Scientific reports · 2025Article
- Easy-to-useMagnetic resonance in medicine · 2025Article
- Blood volume sensitive laminar fMRI with VASO in human hippocampus: Capabilities and biophysical challenges at clinical 7T scanners.bioRxiv : the preprint server for biology · 2025Article
- 7 Tesla fMRI characterisation of the cortical-depth-dependent BOLD response in early human development.bioRxiv : the preprint server for biology · 2025Article
- Article
- Self-supervised predictive learning accounts for cortical layer-specificity.Nature communications · 2025Article
- Article
- Layer-specific BOLD effects in gradient and spin-echo acquisitions in somatosensory cortex.Magnetic resonance in medicine · 2025Article
- Characterizing BOLD activation patterns in the human hippocampus with laminar fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders.Current topics in behavioral neurosciences · 2025Review
- Impact of vascular architecture, oxygen saturation, and hematocrit on human cortical depth-dependent GE- and SE-BOLD fMRI signals: A simulation approach using realistic 3D vascular networks.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Closed-loop fMRI at the mesoscopic scale of columns and layers: Can we do it and why would we want to?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Evaluating the effect of denoising submillimeter auditory fMRI data with NORDIC.Imaging neuroscience (Cambridge, Mass.) · 2024Article
52 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Recent work has established that cerebral blood flow is regulated at a spatial scale that can be resolved by high field fMRI to show cortical columns in humans. While cortical columns represent a cluster of neurons with similar response properties (spanning from the pial surface to the white matter), important information regarding neuronal interactions and computational processes is also contained within a single column, distributed across the six cortical lamina. A basic understanding of underlying neuronal circuitry or computations may be revealed through investigations of the distribution of neural responses at different cortical depths. In this study, we used T(2)-weighted imaging with 0.7 mm (isotropic) resolution to measure fMRI responses at different depths in the gray matter while human subjects observed images with either recognizable or scrambled (physically impossible) objects. Intact and scrambled images were partially occluded, resulting in clusters of activity distributed across primary visual cortex. A subset of the identified clusters of voxels showed a preference for scrambled objects over intact; in these clusters, the fMRI response in middle layers was stronger during the presentation of scrambled objects than during the presentation of intact objects. A second experiment, using stimuli targeted at either the magnocellular or the parvocellular visual pathway, shows that laminar profiles in response to parvocellular-targeted stimuli peak in more superficial layers. These findings provide new evidence for the differential sensitivity of high-field fMRI to modulations of the neural responses at different cortical depths.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.