ArticlePloS one2012
5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 80 citations in OpenAlex.
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- Toxoplasma gondii Infection Decreases Intestinal 5-Lipoxygenase Expression, while Exogenous LTBInfection and immunity · 2022Article
- Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far?Frontiers in pharmacology · 2022Review
- Complex and Controversial Roles of Eicosanoids in Fungal Pathogenesis.Journal of fungi (Basel, Switzerland) · 2021Review
- IL-22 Promotes IFN-γ-Mediated Immunity againstBiomolecules · 2020Article
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- Paradoxical Effect of LTBFrontiers in behavioral neuroscience · 2019Article
- Gene expression analysis of Atlantic salmon gills reveals mucin 5 and interleukin 4/13 as key molecules during amoebic gill disease.Scientific reports · 2018Article
- Excessive localized leukotriene B4 levels dictate poor skin host defense in diabetic mice.JCI insight · 2018Article
- Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice.PLoS pathogens · 2018Article
- Prostaglandins DJournal of lipid research · 2018Article
- Leukotriene BScientific reports · 2017Article
- Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors.Scientific reports · 2017Article
- Too much of a good thing: How modulating LTBSeminars in immunology · 2017Review
- Metabolism-associated danger signal-induced immune response and reverse immune checkpoint-activated CD40Journal of hematology & oncology · 2017Review
- Host-Derived Leukotriene BFrontiers in immunology · 2017Article
- Cytosolic phospholipase A2 contributes to innate immune defense against Candida albicans lung infection.BMC immunology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
5-Lipoxygenase-derived products have been implicated in both the inhibition and promotion of chronic infection. Here, we sought to investigate the roles of endogenous 5-lipoxygenase products and exogenous leukotrienes during Histoplasma capsulatum infection in vivo and in vitro. 5-LO deficiency led to increased lung CFU, decreased nitric oxide production and a deficient primary immune response during active fungal infection. Moreover, H. capsulatum-infected 5-LO(-/-) mice showed an intense influx of neutrophils and an impaired ability to generate and recruit effector T cells to the lung. The fungal susceptibility of 5-LO(-/-) mice correlated with a lower rate of macrophage ingestion of IgG-H. capsulatum relative to WT macrophages. Conversely, exogenous LTB4 and LTC4 restored macrophage phagocytosis in 5-LO deficient mice. Our results demonstrate that leukotrienes are required to control chronic fungal infection by amplifying both the innate and adaptive immune response during histoplasmosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.