ArticleProceedings of the National Academy of Sciences of the United States of America2012
The protein expression landscape of the Arabidopsis root.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- RETICULATA1 is a plastid-localized basic amino acid transporter.Nature plants · 2025Article
- Exploring the untapped potential of single-cell and spatial omics in plant biology.The New phytologist · 2025Review
- Article
- Understanding grain development in the Poaceae family by comparing conserved and distinctive pathways through omics studies in wheat and maize.Frontiers in plant science · 2024Review
- New Insights on the Role of ß-Cyanoalanine Synthase CAS-C1 in Root Hair Elongation through Single-Cell Proteomics.Plants (Basel, Switzerland) · 2023Article
- The proteome landscape of the root cap reveals a role for the jacalin-associated lectin JAL10 in the salt-induced endoplasmic reticulum stress pathway.Plant communications · 2023Article
- Cell type-specific mapping of ion distribution in Arabidopsis thaliana roots.Nature communications · 2023Article
- Proximity Labeling in Plants.Annual review of plant biology · 2023Review
- To the proteome and beyond: advances in single-cell omics profiling for plant systems.Plant physiology · 2022Article
- Alterations in hormonal signals spatially coordinate distinct responses to DNA double-strand breaks inScience advances · 2021Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Physiological and Differential Proteomic Analyses of Imitation Drought Stress Response inInternational journal of molecular sciences · 2020Article
- Shared Genetic Control of Root System Architecture betweenPlant physiology · 2020Article
- QTL mapping for maize starch content and candidate gene prediction combined with co-expression network analysis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- A Comprehensive Toolkit for Inducible, Cell Type-Specific Gene Expression in Arabidopsis.Plant physiology · 2018Article
- Singlet Oxygen Plays an Essential Role in the Root's Response to Osmotic Stress.Plant physiology · 2018Article
- Integration of large-scale data for extraction of integrated Arabidopsis root cell-type specific models.Scientific reports · 2018Article
- GIF Transcriptional Coregulators Control Root Meristem Homeostasis.The Plant cell · 2018Article
- Optimizing FRET-FLIM Labeling Conditions to Detect Nuclear Protein Interactions at Native Expression Levels in Living Arabidopsis Roots.Frontiers in plant science · 2018Article
- A Systems Biology Study in Tomato Fruit Reveals Correlations between the Ascorbate Pool and Genes Involved in Ribosome Biogenesis, Translation, and the Heat-Shock Response.Frontiers in plant science · 2018Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Because proteins are the major functional components of cells, knowledge of their cellular localization is crucial to gaining an understanding of the biology of multicellular organisms. We have generated a protein expression map of the Arabidopsis root providing the identity and cell type-specific localization of nearly 2,000 proteins. Grouping proteins into functional categories revealed unique cellular functions and identified cell type-specific biomarkers. Cellular colocalization provided support for numerous protein-protein interactions. With a binary comparison, we found that RNA and protein expression profiles are weakly correlated. We then performed peak integration at cell type-specific resolution and found an improved correlation with transcriptome data using continuous values. We performed GeLC-MS/MS (in-gel tryptic digestion followed by liquid chromatography-tandem mass spectrometry) proteomic experiments on mutants with ectopic and no root hairs, providing complementary proteomic data. Finally, among our root hair-specific proteins we identified two unique regulators of root hair development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.