ArticleJournal of biomedical materials research. Part A2012
Student award for outstanding research winner in the Ph.D. category for the 9th World Biomaterials Congress, Chengdu, China, June 1-5, 2012: synthesis and application of photodegradable microspheres for spatiotemporal control of protein delivery.
Article in Journal of biomedical materials research. Part A, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Digital Printing of Photoreversible Protective Films.Macromolecular rapid communications · 2026Article
- Photoresponsive Chemistries for User-Directed Hydrogel Network Modulation to Investigate Cell-Matrix Interactions.Accounts of chemical research · 2025Review
- Microgels Formed by Spontaneous Click Chemistries Utilizing Microfluidic Flow Focusing for Cargo Release in Response to Endogenous or Exogenous Stimuli.Pharmaceutics · 2022Article
- Environment Controls Biomolecule Release from Dynamic Covalent Hydrogels.Biomacromolecules · 2021Article
- Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions.Nature communications · 2020Article
- Monitoring Oxygen Levels within Large, Tissue-Engineered Constructs Using Porphyin-Hydrogel Microparticles.ACS biomaterials science & engineering · 2019Article
- Logic-Based Delivery of Site-Specifically Modified Proteins from Environmentally Responsive Hydrogel Biomaterials.Advanced materials (Deerfield Beach, Fla.) · 2019Article
- Epithelial-mesenchymal crosstalk influences cellular behavior in a 3D alveolus-fibroblast model system.Biomaterials · 2018Article
- Cytocompatible Catalyst-Free Photodegradable Hydrogels for Light-Mediated RNA Release To Induce hMSC Osteogenesis.ACS biomaterials science & engineering · 2017Article
- Protease-degradable microgels for protein delivery for vascularization.Biomaterials · 2017Article
- Designing hydrogels for controlled drug delivery.Nature reviews. Materials · 2016Article
- Methods for Generating Hydrogel Particles for Protein Delivery.Annals of biomedical engineering · 2016Review
- Light-triggered chemical amplification to accelerate degradation and release from polymeric particles.Chemical communications (Cambridge, England) · 2015Article
- Design of Thiol- and Light-sensitive Degradable Hydrogels using Michael-type Addition Reactions.Polymer chemistry · 2015Article
- In vitro model alveoli from photodegradable microsphere templates.Biomaterials science · 2015Article
- Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery.Biomacromolecules · 2014Article
- Designing degradable hydrogels for orthogonal control of cell microenvironments.Chemical Society reviews · 2013Review
- Hydrolytically degradable thiol-ene hydrogels for protein release.Macromolecular symposia · 2013Article
- Modeling Controlled Photodegradation in Optically Thick Hydrogels.Journal of polymer science. Part A, Polymer chemistry · 2013Article
- Mechanical Properties and Degradation of Chain and Step Polymerized Photodegradable Hydrogels.Macromolecules · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
In this study, the authors present a photodegradable microparticle system that can be used to entrap and deliver bioactive proteins to cells during culture. By using a photosensitive delivery system, experimenters can achieve a wide variety of spatiotemporally regulated release profiles with a single microparticle formulation, thereby, enabling one to probe many questions as to how protein presentation can be manipulated to regulate cell function. Photodegradable microparticles were synthesized via inverse suspension polymerization with a mean diameter of 22 μm, and degradation was demonstrated upon exposure to several irradiation conditions. The protein-loaded depots were incorporated into cell cultures and release of bioactive protein was quantified during the photodegradation process. This phototriggered release allowed for the delivery of TGF-β1 to stimulate PE25 cells and for the delivery of fluorescently labeled Annexin V to assay apoptotic 3T3 fibroblasts during culture. By incorporating these photoresponsive protein delivery depots into cell culture, new types of experiments are now possible to test hypotheses about how individual or multiple soluble factors might affect cell function when presented in a uniform, temporally varying, or gradient manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.