ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2012
Influence of drug use on morbidity and mortality in heatstroke.
Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Association of short-term ambient environmental exposures with suicide and drug overdose deaths among U.S. veterans.American journal of epidemiology · 2026Article
- Tropical Cyclone Exposure and Psychoactive Drug-Related Death Rates.JAMA network open · 2026Article
- A Cross-Sectional Study of Stimulant Use among Migrant and Seasonal Agricultural Workers in Eastern North Carolina.Journal of immigrant and minority health · 2025Article
- Exploring the relationship between medications and heat-related community deaths during the 2021 heat dome: a hybrid approach using machine learning.EBioMedicine · 2025Article
- Climate change is a health crisis with opportunities for health care action: A focus on health care providers, patients with asthma and allergic immune diseases, and their families and neighbors.The Journal of allergy and clinical immunology · 2023Review
- Climate Change, Skin Health, and Dermatologic Disease: A Guide for the Dermatologist.American journal of clinical dermatology · 2023Review
- Analysis of heat stroke and heat exhaustion cases in EudraVigilance pharmacovigilance database.European journal of clinical pharmacology · 2023Article
- Global warming, heat-related illnesses, and the dermatologist.International journal of women's dermatology · 2021Review
- Drug-associated non-pyrogenic hyperthermia: a narrative review.European journal of clinical pharmacology · 2020Review
- Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model.Molecular medicine reports · 2017Article
- Racial and socioeconomic disparities in heat-related health effects and their mechanisms: a review.Current epidemiology reports · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous medications and illicit drugs can predispose an individual to heat illness, primarily by altering thermoregulation by either increasing endogenous heat production or impairing heat dissipation. This study sought to determine if use of such drugs was associated with more severe illness in patients presenting with heatstroke. A case control study was conducted on adult patients (age, ≥14 years) admitted to an intensive care unit with an admitting diagnosis of heatstroke at two academic teaching hospitals in Phoenix, AZ, between 31 August 2005 through 31 July 2010. Subjects were classified as "users" if they admitted to taking a drug on a pre-defined list of drugs associated with abnormal thermal homeostasis, or if a urine test for drugs of abuse revealed the presence of an amphetamine or cocaine. Similarly, subjects who did not take such drugs were considered "non-users." Seventy-eight patients were identified, with complete medication histories available for 74 of 78 subjects. The overall prevalence of drug utilization was 41.9 % (31 of 74). The median length of stay was 3.0 days for the non-users compared with 9.0 days for "users." There was no difference between users and non-users with regard to mortality. Drugs that impair thermoregulation are frequently encountered in patients admitted for heatstroke. Patients taking such drugs may experience increased morbidity over those patients not taking such drugs.
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Registered trials
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