Trial reportHuman reproduction (Oxford, England)2012
Sperm gene expression profile is related to pregnancy rate after insemination and is predictive of low fecundity in normozoospermic men.
Trial report in Human reproduction (Oxford, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Candidate Transcript Panel in Semen Extracellular Vesicles Can Improve Prediction of Aggressiveness of Prostate Cancer.International journal of molecular sciences · 2025Article
- Evaluation of Risk Factors and a Gene Panel as a Tool for Unexplained Infertility Diagnosis by Next-Generation Sequencing.Medicina (Kaunas, Lithuania) · 2025Review
- Yoga and its effect on sperm genomic integrity, gene expression, telomere length and perceived quality of life in early pregnancy loss.Scientific reports · 2024Article
- Article
- Identification of hub genes and their expression profiling for predicting buffalo (Bubalus bubalis) semen quality and fertility.Scientific reports · 2023Article
- The construction of a testis transcriptional cell atlas from embryo to adult reveals various somatic cells and their molecular roles.Journal of translational medicine · 2023Article
- Using Small Non-Coding RNAs in Extracellular Vesicles of Semen as Biomarkers of Male Reproductive System Health: Opportunities and Challenges.International journal of molecular sciences · 2023Review
- Integration of omics studies indicates that species-dependent molecular mechanisms govern male fertility.Journal of animal science and biotechnology · 2023Article
- PITHD1 is a proteasome-interacting protein essential for male fertilization.The Journal of biological chemistry · 2020Article
- The sperm factor: paternal impact beyond genes.Heredity · 2018Review
- RNA sequencing as a powerful tool in searching for genes influencing health and performance traits of horses.Journal of applied genetics · 2016Review
- Confrontation, Consolidation, and Recognition: The Oocyte's Perspective on the Incoming Sperm.Cold Spring Harbor perspectives in medicine · 2015Review
- OMICS: Current and future perspectives in reproductive medicine and technology.Journal of human reproductive sciences · 2014Review
- A clinical appraisal of the genetic basis in unexplained male infertility.Journal of human reproductive sciences · 2013Review
- New genetic markers for male fertility.Asian journal of andrology · 2012Article
- Sperm glyceraldehyde 3-phosphate dehydrogenase gene expression in asthenozoospermic spermatozoa.Asian journal of andrologyArticle
- Sperm selection in natural conception: what can we learn from Mother Nature to improve assisted reproduction outcomes?Human reproduction updateReview
- Increased expression of PELP1 in human sperm is correlated with decreased semen quality.Asian journal of andrologyArticle
- Gene transcription profiling of astheno- and normo-zoospermic sperm subpopulations.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssessment of male fertility is traditionally based on microscopic evaluation of semen. However, the classical semen parameters do not adequately reflect sperm function, and their clinical value in predicting fertility is limited. We hypothesize that the sperm expression profile could reflect the fertilizing quality of spermatozoa and could be more informative for predicting the in vivo reproductive fitness of men with normal semen parameters.
methodsSperm gene expression patterns of 68 normozoospermic donors (43 Phase I and 25 Phase II), used for therapeutic IUI, were analysed via TaqMan Arrays.
resultsSignificant differences in the expression of individual genes were observed between groups of donors with the lowest and highest pregnancy rates (PRs) after IUI. Additionally, we have developed a molecular means to classify the fertility status of semen donors for IUI based on the expression signature of four genes. In the Phase I study, this model had 90% sensitivity and 97% specificity for discriminating donors resulting in low PRs (cut-off value: <13.6%), far better than that obtained from the combination of sperm parameters. The translation of the model was validated in Phase II donors resulting in a sensitivity of 71.5% and a specificity of 78%.
conclusionsOur findings contribute to the search for the most valuable genetic markers which are potentially useful as tools for predicting pregnancy. Our expression model could complement classical semen analysis in order to identify sperm donors with a less favourable IUI reproductive outcome despite having normal semen parameters. It may also be useful for the study of sperm function in couples with unexplained infertility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.