ArticleApplied and environmental microbiology2012
Polymorphisms in rpoS and stress tolerance heterogeneity in natural isolates of Cronobacter sakazakii.
Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 52 citations in OpenAlex.
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- Random Mutagenesis Applied to Reveal Factors Involved in Oxidative Tolerance and Biofilm Formation in FoodborneFrontiers in microbiology · 2019Article
- The General Stress Response Is Conserved in Long-Term Soil-Persistent Strains of Escherichia coli.Applied and environmental microbiology · 2016Article
- Hfq plays important roles in virulence and stress adaptation in Cronobacter sakazakii ATCC 29544.Infection and immunity · 2015Article
- Plasmid-encoded MCP is involved in virulence, motility, and biofilm formation of Cronobacter sakazakii ATCC 29544.Infection and immunity · 2015Article
- Cronobacter: an emerging opportunistic pathogen associated with neonatal meningitis, sepsis and necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2013Review
- Selection for loss of RpoS in Cronobacter sakazakii by growth in the presence of acetate as a carbon source.Applied and environmental microbiology · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significant phenotypic diversity was observed when we examined the abilities of a number of Cronobacter sakazakii natural isolates to cope with various sublethal stress conditions (acid, alkaline, osmotic, oxidative, or heat stress). Levels of catalase activity and use of acetate as a carbon source, phenotypes commonly used as indirect assays to predict RpoS function, revealed a high correlation between predicted RpoS activity and tolerance to acid, alkaline, osmotic, and oxidative treatments. The rpoS genes were sequenced and analyzed for polymorphisms. Loss-of-function mutations were found in two strains; C. sakazakii DPC 6523 and the genome-sequenced strain C. sakazakii ATCC BAA-894. The complementation of these strains with a functional rpoS gene resulted in an increase in bacterial tolerance to acid, osmotic, and oxidative stresses. The pigmentation status of strains was also assessed, and a high variability in carotenoid content was observed, with a functional rpoS gene being essential for the production of the characteristic yellow pigment. In conclusion, the evidence presented in this study demonstrates that rpoS is a highly polymorphic gene in C. sakazakii, and it supports the importance of RpoS for the tolerance under stress conditions that C. sakazakii may encounter in the food chain and in the host during infection.
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