ArticleInflammatory bowel diseases2012
Common NOD2 risk variants in African Americans with Crohn's disease are due exclusively to recent Caucasian admixture.
Article in Inflammatory bowel diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 24 citations in OpenAlex.
- GPR15-guided CD8Nature · 2026Article
- Towards IBD Prediction and Prevention: The Contribution of Genetics and Genomics.Inflammatory bowel diseases · 2025Review
- Phenome-wide association study of monogenic inflammatory bowel disease genes in diverse biobanks identifies population-specific and shared Goldilocks alleles: implications for Precision Medicine.Journal of Crohn's & colitis · 2025Article
- Multimodal single-cell analyses reveal mechanisms of perianal fistula in diverse patients with Crohn's disease.Med (New York, N.Y.) · 2024Article
- Gut microbiome composition reveals the distinctiveness between the Bengali people and the Indigenous ethnicities in Bangladesh.Communications biology · 2024Article
- The role of admixture in the rare variant contribution to inflammatory bowel disease.Genome medicine · 2023Article
- Local genetic variation of inflammatory bowel disease in Basque population and its effect in risk prediction.Scientific reports · 2022Article
- Common and Rare Variant Prediction and Penetrance of IBD in a Large, Multi-ethnic, Health System-based Biobank Cohort.Gastroenterology · 2021Article
- African Ancestry Proportion Influences Ileal Gene Expression in Inflammatory Bowel Disease.Cellular and molecular gastroenterology and hepatology · 2020Article
- Targeted Gene Sequencing in Children with Crohn's Disease and Their Parents: Implications for Missing Heritability.G3 (Bethesda, Md.) · 2018Article
- IBD Serology and Disease Outcomes in African Americans With Crohn's Disease.Inflammatory bowel diseases · 2017Article
- Reply.Gastroenterology · 2017Article
- Common NOD2/CARD15 and TLR4 Polymorphisms Are Associated with Crohn's Disease Phenotypes in Southeastern Brazilians.Digestive diseases and sciences · 2016Article
- Genetic Influences on the Development of Fibrosis in Crohn's Disease.Frontiers in medicine · 2016Review
- Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans.Gastroenterology · 2015Article
- Genetics of Inflammatory Bowel Diseases.Gastroenterology · 2015Review
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12 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCrohn's disease (CD) is highly heritable. NOD2 has emerged as the main susceptibility gene among individuals of European ancestry; however, NOD2 does not appear to contribute to CD susceptibility among many non-European populations. Today's African American (AA) population represents an admixture of West African (80%) and European (20%) ancestry. Since genotype-based tools are becoming increasingly available for CD, it is important that we validate the risk variants in different populations, such as admixed AAs.
methodsWe analyzed the NOD2 variants among admixed AAs (n = 321, 240 with CD and 111 healthy controls [HCs]) and nonadmixed West Africans (n = 40) by genotyping four known disease-causing NOD variants. We extracted the publicly available 1000 Genomes data on NOD2 variants from 500 subjects of West African origin. Association with disease was evaluated by logistic regression.
resultsAn association with CD was found for the classical single nucleotide polymorphism (SNP) 1007fs (2.6% CD, 0% HC, P = 0.012); there was no association when the genotypic and allelic frequencies of the risk alleles were compared for SNPs R702W and G908R. No known NOD2 risk alleles were seen in either the West African cohort or in subjects of African ancestry from the 1000 Genomes project.
conclusionsThe NOD2 gene is a risk for CD in AAs, although the allele frequencies and the attributable risk are much lower compared with Caucasians. The risk alleles are not seen in the West African population, suggesting that the risk for CD contributed by NOD2 among AAs is due exclusively to recent European admixture.
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