ArticleMagma (New York, N.Y.)2012
Correlating brain blood oxygenation level dependent (BOLD) fractal dimension mapping with magnetic resonance spectroscopy (MRS) in Alzheimer's disease.
Article in Magma (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Fractal analysis in radiological and nuclear medicine perfusion imaging: a systematic review.European radiology · 2014Pooled it
- Morphology and Fractal-Based Classifications of Neurons and Microglia in Two and Three Dimensions.Advances in neurobiology · 2024Review
- Monofractal analysis of functional magnetic resonance imaging: An introductory review.Human brain mapping · 2022Review
- Biofabrication strategies for creating microvascular complexity.Biofabrication · 2019Review
- Fractal Analysis of Brain Blood Oxygenation Level Dependent (BOLD) Signals from Children with Mild Traumatic Brain Injury (mTBI).PloS one · 2017Article
- Temporal fractal analysis of the rs-BOLD signal identifies brain abnormalities in autism spectrum disorder.PloS one · 2017Article
- Disruption of resting functional connectivity in Alzheimer's patients and at-risk subjects.Current neurology and neuroscience reports · 2014Review
- A preliminary study on the effects of acute ethanol ingestion on default mode network and temporal fractal properties of the brain.Magma (New York, N.Y.) · 2014Article
- 7.0T nuclear magnetic resonance evaluation of the amyloid beta (1-40) animal model of Alzheimer's disease: comparison of cytology verification.Neural regeneration research · 2014Article
- Does the brain's E:I balance really shape long-range temporal correlations? Lessons learned from 3T MRI.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo correlate temporal fractal structure of resting state blood oxygen level dependent (rsBOLD) functional magnetic resonance imaging (fMRI) with in vivo proton magnetic resonance spectroscopy ((1)H-MRS), in Alzheimer's disease (AD) and healthy age-matched normal controls (NC). MATERIALS AND
methodsHigh temporal resolution (4 Hz) rsBOLD signal and single voxel (left putamen) magnetic resonance spectroscopy data was acquired in 33 AD patients and 13 NC. The rsBOLD data was analyzed using two types of fractal dimension (FD) analysis based on relative dispersion and frequency power spectrum. Comparisons in FD were performed between AD and NC, and FD measures were correlated with (1)H-MRS findings.
resultsTemporal fractal analysis of rsBOLD, was able to differentiate AD from NC subjects (P = 0.03). Low FD correlated with markers of AD severity including decreased concentrations of N-acetyl aspartate (R = 0.44, P = 0.015) and increased myoinositol (mI) (R = -0.45, P = 0.012).
conclusionBased on these results we suggest fractal analysis of rsBOLD could provide an early marker of AD.
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