Trial reportBMJ (Clinical research ed.)2012
Effect of offering different levels of support and free nicotine replacement therapy via an English national telephone quitline: randomised controlled trial.
Trial report in BMJ (Clinical research ed.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00775944 (Trial Comparing Different Methods of Support With Stopping Smoking Offered Through The National Health Service), which is not on this map. Cited by 31 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trial Comparing Different Methods of Support With Stopping Smoking Offered Through The National Health Service (NHS) Smoking Helpline
Who cites it
31 citing papers in PubMed, 9 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Korean Clinical Practice Guideline of Korean Society for Research on Nicotine and Tobacco (KSRNT) and National Evidence-based Healthcare Collaborating Agency (NECA) on Treatment of Tobacco Use 2024.Journal of Korean medical science · 2025Guideline
- Differences in the effectiveness of individual-level smoking cessation interventions by socioeconomic status.The Cochrane database of systematic reviews · 2025Pooled it
- Cessation classification likelihood increases with higher expired-air carbon monoxide cutoffs: a meta-analysis.Drug and alcohol dependence · 2021Pooled it
- Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation.The Cochrane database of systematic reviews · 2019Pooled it
- Telephone counselling for smoking cessation.The Cochrane database of systematic reviews · 2019Pooled it
- Nicotine replacement therapy versus control for smoking cessation.The Cochrane database of systematic reviews · 2018Pooled it
- Psychosocial interventions for supporting women to stop smoking in pregnancy.The Cochrane database of systematic reviews · 2017Pooled it
- Combined pharmacotherapy and behavioural interventions for smoking cessation.The Cochrane database of systematic reviews · 2016Pooled it
- Psychosocial interventions for supporting women to stop smoking in pregnancy.The Cochrane database of systematic reviews · 2013Pooled it
- A Randomized Controlled Trial of an Optimized Smoking Treatment Delivered in Primary Care.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018Trial
- Helping Hospitalized Smokers: A Factorial RCT of Nicotine Patches and Counseling.American journal of preventive medicine · 2016Trial
- Trial
- Does use of 'non-trial' cessation support help explain the lack of effect from offering NRT to quitline callers in a RCT?Tobacco control · 2014Trial
- Enhancing tobacco quitline effectiveness: identifying a superior pharmacotherapy adjuvant.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013Trial
- Instant messaging-delivered brief motivational interviewing for noncommunicable disease patients with no intention to quit smoking.NPJ digital medicine · 2026Article
- Evaluating the implementation of adult smoking cessation programs in community settings: a scoping review.Frontiers in public health · 2024Article
- A smoking quitline integrated with clinician counselling at outpatient health facilities in Vietnam: a single-arm prospective cohort study.BMC public health · 2022Article
- Comparison of saliva cotinine and exhaled carbon monoxide concentrations when smoking and after being offered dual nicotine replacement therapy in pregnancy.Addiction (Abingdon, England) · 2022Article
- Study protocol for a telephone-based smoking cessation randomized controlled trial in the lung cancer screening setting: The lung screening, tobacco, and health trial.Contemporary clinical trials · 2019Article
- Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 7 institutions in 2 countries.
Funding
Abstract
objectiveTo compare the effects of free nicotine replacement therapy or proactive telephone counselling in addition to standard smoking cessation support offered through a telephone quitline.
designParallel group, 2 × 2 factorial, randomised controlled trial.
settingNational quitline, England.
participants2591 non-pregnant smokers aged 16 or more residing in England who called the quitline between February 2009 and February 2010 and agreed to set a quit date: 648 were each randomised to standard support, proactive support, or proactive support with nicotine replacement therapy, and 647 were randomised to standard support with nicotine replacement therapy.
interventionsTwo interventions were offered in addition to standard support: six weeks' nicotine replacement therapy, provided free, and proactive counselling sessions (repeat telephone calls from, and interaction with, cessation advisors).
main outcome measuresThe primary outcome was self reported smoking cessation for six or more months after the quit date. The secondary outcome was cessation validated by exhaled carbon monoxide measured at six or more months.
resultsAt six months, 17.7% (n = 229) of those offered nicotine replacement therapy reported smoking cessation compared with 20.1% (n = 261) not offered such therapy (odds ratio 0.85, 95% confidence interval 0.70 to 1.04), and 18.2% (n = 236) offered proactive counselling reported smoking cessation compared with 19.6% (n = 254) offered standard support (0.91, 0.75 to 1.11). Data validated by carbon monoxide readings changed the findings for nicotine replacement therapy only, with smoking cessation validated in 6.6% (85/1295) of those offered nicotine replacement therapy compared with 9.4% (122/1296) not offered such therapy (0.67, 0.50 to 0.90).
conclusionsOffering free nicotine replacement therapy or additional (proactive) counselling to standard helpline support had no additional effect on smoking cessation.
trial registrationClinicalTrials.gov NCT00775944.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.