ArticleNature cell biology2012
Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila.
Article in Nature cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Biophysics of lumen morphogenesis.Development (Cambridge, England) · 2026Review
- Single-cell lineage tracing techniques in hematology: unraveling the cellular narrative.Journal of translational medicine · 2025Review
- The dynamics of tubulogenesis in development and disease.Development (Cambridge, England) · 2025Review
- Article
- An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function.Nature communications · 2023Article
- Article
- Lateral adherens junctions mediate a supracellular actomyosin cortex in drosophila trachea.iScience · 2023Article
- Temporal-spatial low shear stress induces heterogenous distribution of hematopoietic stem cell budding in zebrafish.Cellular and molecular life sciences : CMLS · 2022Article
- Correct regionalization of a tissue primordium is essential for coordinated morphogenesis.eLife · 2021Article
- Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity.Developmental cell · 2021Article
- Sex dependent effect of maternal e-nicotine on F1 Drosophila development and airways.Scientific reports · 2021Article
- Bitbow Enables Highly Efficient Neuronal Lineage Tracing and Morphology Reconstruction in SingleFrontiers in neural circuits · 2021Article
- Long-term in vivo imaging of Drosophila larvae.Nature protocols · 2020Article
- Yorkie controls tube length and apical barrier integrity during airway development.The Journal of cell biology · 2019Article
- Extracellular matrix stiffness cues junctional remodeling for 3D tissue elongation.Nature communications · 2019Article
- Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors.Nature communications · 2019Article
- QuBiT: a quantitative tool for analyzing epithelial tubes reveals unexpected patterns of organization in theDevelopment (Cambridge, England) · 2019Article
- WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis.Nature communications · 2019Article
- A small proportion of Talin molecules transmit forces at developing muscle attachments in vivo.PLoS biology · 2019Article
- The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation.PLoS genetics · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
Although many organ functions rely on epithelial tubes with correct dimensions, mechanisms underlying tube size control are poorly understood. We analyse the cellular mechanism of tracheal tube elongation in Drosophila, and describe an essential role of the conserved tyrosine kinase Src42A in this process. We show that Src42A is required for polarized cell shape changes and cell rearrangements that mediate tube elongation. In contrast, diametric expansion is controlled by apical secretion independently of Src42A. Constitutive activation of Src42A induces axial cell stretching and tracheal overelongation, indicating that Src42A acts instructively in this process. We propose that Src42A-dependent recycling of E-Cadherin at adherens junctions is limiting for cell shape changes and rearrangements in the axial dimension of the tube. Thus, we define distinct cellular processes that independently control axial and diametric expansion of a cylindrical epithelium in a developing organ. Whereas exocytosis-dependent membrane growth drives circumferential tube expansion, Src42A is required to orient membrane growth in the axial dimension of the tube.
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Registered trials
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