ArticleCommunicative & integrative biology2011
Vesicular calcium channels as regulators of the exocytotic post-fusion phase.
Article in Communicative & integrative biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Possible Roles for Purinergic Receptor P2RX4 in Breast and Prostate Cancers.International journal of molecular sciences · 2025Review
- Pharmacological differences between human and mouse P2X4 receptor explored using old and new tools.Purinergic signalling · 2024Article
- Inflammation-induced upregulation of P2XAmerican journal of physiology. Lung cellular and molecular physiology · 2019Article
- SNAP23-Dependent Surface Translocation of Leukotriene B4 (LTB4) Receptor 1 Is Essential for NOX2-Mediated Exocytotic Degranulation in Human Mast Cells Induced by Trichomonas vaginalis-Secreted LTB4.Infection and immunity · 2017Article
- Agonist-dependent modulation of cell surface expression of the cold receptor TRPM8.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Synaptotagmin-7 links fusion-activated Ca²⁺ entry and fusion pore dilation.Journal of cell science · 2014Article
- A new role for P2X4 receptors as modulators of lung surfactant secretion.Frontiers in cellular neuroscience · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulated secretion is a fundamental cellular process in many different types of eukaryotic cells with Ca2(+-)triggered exocytosis taking centre stage. Elevations of the cytoplasmic Ca(2+) concentration ([Ca(2+)](c)) regulate multiple steps from vesicle fusion with the plasma membrane to fusion pore dilation and subsequent retrieval of spent vesicles. The general view is that the rise in [Ca(2+)](c) initiates during the pre-fusion stage and either results from Ca(2+)-influx via Ca(2+) channels in the plasma membrane or from release from intracellular Ca(2+)-stores. However, there is increasing evidence that exocytosis of secretory vesicles triggers additional, localised Ca(2+) signals via insertion of vesicle-associated Ca(2+) channels into the cell surface. These restricted Ca(2+) signals following fusion are ideally suited for regulating the post-fusion fate of individual secretory vesicles. In invertebrates they have been shown to trigger compensatory endocytosis. Recently we have reported that exocytosis of lamellar bodies in alveolar type II epithelial cells results in a localized Ca(2+)-influx via vesicular P2X(4) receptors which regulates fusion pore expansion and vesicle content release. This finding expands the emerging picture that post-fusion Ca(2+) entry via vesicle-associated Ca(2+) channels plays a central role for regulated exocytosis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.