ArticleCommunicative & integrative biology2011
Cla4, but not Rac1, regulates the filamentous response of Ustilago maydis to low ammonium conditions.
Article in Communicative & integrative biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Cla4A, a Novel Regulator of Gene Expression Networks Required for Asexual and Insect-Pathogenic Lifecycles ofInternational journal of molecular sciences · 2024Article
- An OptimizedJournal of fungi (Basel, Switzerland) · 2020Article
- Integrated strain- and process design enable production of 220 g LBiotechnology for biofuels · 2019Article
- The putative phospholipase Lip2 counteracts oxidative damage and influences the virulence of Ustilago maydis.Molecular plant pathology · 2017Article
- Physical and genetic interaction between ammonium transporters and the signaling protein Rho1 in the plant pathogen Ustilago maydis.Eukaryotic cell · 2014Article
- Defects in mitochondrial and peroxisomal β-oxidation influence virulence in the maize pathogen Ustilago maydis.Eukaryotic cell · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ustilago maydis, the fungal pathogen of maize, undergoes a dimorphic transition from budding yeast-like growth to filamentous growth, both as part of its program for pathogenesis and distinctly, in response to environmental cues, such as acid pH or low nitrogen availability. Smu1 is a p21-activated protein kinase (PAK) with roles in both the mating response required for the former function, as well as for the nutrient response. Hsl7 may be a negative regulator of Smu1 and appears to play a role in cell length and cell cycle. Additional proteins that participate in cell polarity and filamentation pathways include the small G protein, Rac1, and its effector PAK kinase, Cla4. Here we describe further experiments that explore the roles of Cla4 and Rac1 in the response to nitrogen availability. While deletion of rac1severely delays filamentous growth on solid media low in ammonium (SLAD), we found that deletion of cla4 does not abolish filamentous cell morphology on solid SLAD. Unexpectedly, however, the Dcla4 mutants also filament in liquid SLAD. The filamentous cell morphology of the cla4 mutant in liquid SLAD has only been seen previously for one other mutant, a strain deleted for hsl7 that simultaneously over-expresses smu1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.