Evidence map›Paper›PMID 22446523›Full record

ArticleCommunicative & integrative biology2011

The next phase of life-sciences spaceflight research: Harnessing the power of functional genomics.

Timothy Etheridge, Kanako Nemoto, Toko Hashizume, Chihiro Mori, Tomoko Sugimoto, Hiromi Suzuki, Keiji Fukui, Takashi Yamazaki, Akira Higashibata, Nathaniel J Szewczyk and 1 more

Open access · goldAbstract read
In one paragraph

Article in Communicative & integrative biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Evaluation of the Fluids Mixing Enclosure System for Life Science Experiments During a CommercialAdvances in space research : the official journal of the Committee on Space Research (COSPAR) · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Timothy Etheridge
Kanako Nemoto
Toko Hashizume
Chihiro Mori
Tomoko Sugimoto
Hiromi Suzuki
Keiji Fukui
Takashi Yamazaki
Akira Higashibata
Nathaniel J Szewczyk
Atsushi Higashitani
Tohoku University · JPJapan Aerospace Exploration Agency · JPJapan Space Forum · JPAdvanced Engineering Services (Japan) · JPInstitute of Space and Astronautical Science · JPRoyal Derby Hospital · GBUniversity of Nottingham · GB

Funding

Gene Networks Regulating Muscle Protein DegradationR01AR054342 · NIAMS · UNIVERSITY OF NOTTINGHAM · PI SZEWCZYK, NATHANIEL J. · 2007 to 2010
$902k
Medical Research Council G0801271NIAMS NIH HHS R01 AR054342
6 · The paper itself

Abstract

Recently we demonstrated that the effectiveness of RNAi interference (RNAi) for inhibiting gene expression is maintained during spaceflight in the worm Caenorhabditis elegans and argued for the biomedical importance of this finding. We also successfully utilized green fluorescent protein (GFP)-tagged proteins to monitor changes in GPF localization during flight. Here we discuss potential applications of RNAi and GFP in spaceflight studies and the ramifications of these experiments for the future of space life-sciences research.

Identifiers

PMID22446523
PMCPMC3306327
OpenAlexW2008975197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.