ArticleCommunicative & integrative biology2011
An archaeal origin for the actin cytoskeleton: Implications for eukaryogenesis.
Article in Communicative & integrative biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- The Importance of the Plasma Membrane in Atherogenesis.Membranes · 2022Review
- Culexarchaeia, a novel archaeal class of anaerobic generalists inhabiting geothermal environments.ISME communications · 2022Article
- Atomic insights into the genesis of cellular filaments by globular proteins.Nature structural & molecular biology · 2018Article
- Article
- Bacterial cell biology outside the streetlight.Environmental microbiology · 2016Review
- On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype.Trends in cell biology · 2016Review
- The Cytoskeleton and Its Regulation by Calcium and Protons.Plant physiology · 2016Review
- Origin of eukaryotes from within archaea, archaeal eukaryome and bursts of gene gain: eukaryogenesis just made easier?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Exploring microbial dark matter to resolve the deep archaeal ancestry of eukaryotes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Horizontal gene flow from Eubacteria to Archaebacteria and what it means for our understanding of eukaryogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Archaeal actin from a hyperthermophile forms a single-stranded filament.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Origin and evolution of the self-organizing cytoskeleton in the network of eukaryotic organelles.Cold Spring Harbor perspectives in biology · 2014Review
- The archaeal legacy of eukaryotes: a phylogenomic perspective.Cold Spring Harbor perspectives in biology · 2014Review
- The dispersed archaeal eukaryome and the complex archaeal ancestor of eukaryotes.Cold Spring Harbor perspectives in biology · 2014Review
- Close encounters of the third domain: the emerging genomic view of archaeal diversity and evolution.Archaea (Vancouver, B.C.) · 2013Review
- Breaking through a phylogenetic impasse: a pair of associated archaea might have played host in the endosymbiotic origin of eukaryotes.Cell & bioscience · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A hallmark of the eukaryotic cell is the actin cytoskeleton, involved in a wide array of processes ranging from shape determination and phagocytosis to intracellular transport and cytokinesis. Recently, we reported the discovery of an actin-based cytoskeleton also in Archaea. The archaeal actin ortholog, Crenactin, was shown to belong to a conserved operon, Arcade (actin-related cytoskeleton in Archaea involved in shape determination), encoding an additional set of cytoskeleton-associated proteins. Here, we elaborate on the implications of these findings for the evolutionary relation between archaea and eukaryotes, with particular focus on the possibility that eukaryotic actin and actin-related proteins have evolved from an ancestral archaeal actin gene. Archaeal actin could thus have played an important role in cellular processes essential for the origin and early evolution of the eukaryotic lineage. Further exploration of uncharacterized archaeal lineages is necessary to find additional missing pieces in the evolutionary trajectory that ultimately gave rise to present-day organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.