ArticleSocial cognitive and affective neuroscience2013
Common representation of pain and negative emotion in the midbrain periaqueductal gray.
Article in Social cognitive and affective neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies.Neuroscience and biobehavioral reviews · 2018Pooled it
- Cognitive reappraisal of emotion: a meta-analysis of human neuroimaging studies.Cerebral cortex (New York, N.Y. : 1991) · 2014Pooled it
- Frontal-Brainstem Pathways Mediating Placebo Effects on Social Rejection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Trial
- Pain modulation by intranasal oxytocin and emotional picture viewing - a randomized double-blind fMRI study.Scientific reports · 2016Trial
- Identification of discrete functional subregions of the human periaqueductal gray.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Somatic Symptom Disorder Is Associated with Cough Hypersensitivity and Poor Response to Anti-Reflux Therapy in Patients with Gastroesophageal Reflux-Induced Chronic Cough.Journal of clinical medicine · 2026Article
- Chronic stress increases the susceptibility to chronic vulvar pain following acute vulvar inflammation in a preclinical model of vulvodynia.Molecular brain · 2026Article
- A neurofunctional signature of affective arousal generalizes across valence domains and distinguishes subjective experience from autonomic reactivity.Nature communications · 2025Article
- Cortical representations of affective pain shape empathic fear in male mice.Nature communications · 2025Article
- Unveiling the Truth in Pain: Neural and Behavioral Distinctions Between Genuine and Deceptive Pain.Brain sciences · 2025Article
- Cerebellar functional connectivity relates to lower urinary tract function: A 7 Tesla study.Neurourology and urodynamics · 2024Article
- Abnormal Degree Centrality in Zoster-Associated Pain with or Without Psychiatric Comorbidities: A Resting-State Functional MRI Study.Journal of pain research · 2024Article
- Emotional regulation strategies in daily life: the intensity of emotions and regulation choice.Frontiers in psychology · 2023Article
- Neuronal Encoding of Emotional Valence and Intensity in the Monkey Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Mindfulness-Based Stress Reduction, Cognitive Behavioral Therapy, and Acupuncture in Chronic Low Back Pain: Protocol for Two Linked Randomized Controlled Trials.JMIR research protocols · 2022Article
- The interrelationship of chronic cough and depression: a prospective population-based study.ERJ open research · 2022Article
- Anatomical Evidence for the Neural Connection from the Emotional Brain to Autonomic Innervation in the Anterior Chamber Structures of the Eye.Current medical science · 2022Article
- Review
- Training intervention effects on cognitive performance and neuronal plasticity-A pilot study.Frontiers in neurology · 2022Article
- The neural correlates of context driven changes in the emotional response: An fMRI study.PloS one · 2022Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
Human neuroimaging offers a powerful way to connect animal and human research on emotion, with profound implications for psychological science. However, the gulf between animal and human studies remains a formidable obstacle: human studies typically focus on the cortex and a few subcortical regions such as the amygdala, whereas deeper structures such as the brainstem periaqueductal gray (PAG) play a key role in animal models. Here, we directly assessed the role of PAG in human affect by interleaving in a single fMRI session two conditions known to elicit strong emotional responses--physical pain and negative image viewing. Negative affect and PAG activity increased in both conditions. We next examined eight independent data sets, half featuring pain stimulation and half negative image viewing. In sum, these data sets comprised 198 additional participants. We found increased activity in PAG in all eight studies. Taken together, these findings suggest PAG is a key component of human affective responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.