Evidence map›Paper›PMID 22446158›Full record

ReviewArchives of biochemistry and biophysics2012

Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase.

J S Adams, M Hewison

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Archives of biochemistry and biophysics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 9 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 9 syntheses or guidelines pooled it, 260 citations in OpenAlex.

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  13. A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.Journal of the American Society of Nephrology : JASN · 2017
    Trial
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  15. Long-term cholecalciferol administration in hemodialysis patients: a single-center randomized pilot study.Medical science monitor : international medical journal of experimental and clinical research · 2014
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79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

J S AdamsOrthopaedic Hospital Research Center, UCLA/Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-7358, USA. jsadams@mednet.ucla.edu
M Hewison
Orthopaedic Hospital · USUniversity of California, Los Angeles · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
Role of Vitamin D Prohormone 25-OHD in the Innate Immune Response to TuberculosisR01AI073539 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2008 to 2012
$2.0M
NCATS NIH HHS UL1 TR000124NCRR NIH HHS UL1 RR033176NIAID NIH HHS R01 1AI073539NIAID NIH HHS R01 AI073539
6 · The paper itself

Abstract

Like the vitamin D receptor (VDR), the CYP27B1-hydroxylase is expressed widely in human tissues. This expression profile establishes the potential for interaction of the VDR with the product of the CYP27B1, 1,25-dihydroxyvitamin D (1,25-(OH)(2)D), in either an intracrine or paracrine mode. This expansive expression profile also suggests that the local production and action of 1,25-(OH)(2)D to regulate VDR-directed gene expression may be similarly wide-ranging and distinct from what occurs in the kidney; the proximal renal tubular epithelial cell is the richest source of the CYP27B1 and the site for production of 1,25-(OH)(2)D destined to function as a hormone. Existence of the CYP27B1 at extrarenal sites has been widely documented, although the functional impact of the enzyme in these tissues has yet to be fully demonstrated. Two notable exceptions are the disease-activated macrophage (e.g., in sarcoidosis or tuberculosis) and the placenta. These two tissues are capable of generating enough 1,25-(OH)(2)D so as to be detectable in the general circulation. As such, this review will focus on CYP27B1 expression only at these two sites, theorizing that 1,25-(OH)(2)D production at these sites is for the purpose of local immunoregulatory function, not for controlling calcium balance in the host or the fetus.

Indexed as

Gene Expression Regulation, Enzymologic25-Hydroxyvitamin D3 1-alpha-HydroxylaseAnimalsFemaleHumansImmunity, InnateMacrophagesPlacentaPregnancyVitamin D1,25-dihydroxyvitamin D25-Hydroxyvitamin D3 1-alpha-HydroxylaseVitamin D

Identifiers

PMID22446158
PMCPMC3361592
OpenAlexW2036640577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.