Evidence map›Paper›PMID 22446010›Full record

ReviewCurrent opinion in neurobiology2012

Dynamical changes in neurological diseases and anesthesia.

Michelle M McCarthy, ShiNung Ching, Miles A Whittington, Nancy Kopell

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Rhythm and Synchrony in a Cortical Network Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michelle M McCarthyDepartment of Mathematics and Statistics, Boston University, Boston, MA 02215, United States.
ShiNung Ching
Miles A Whittington
Nancy Kopell

Funding

CRCNS: Gamma Rhythms and Cell AssembliesR01NS067199 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KOPELL, NANCY · 2009 to 2013
$1.7M
NINDS NIH HHS R01 NS067199
6 · The paper itself

Abstract

Dynamics of neuronal networks can be altered in at least two ways: by changes in connectivity, that is, the physical architecture of the network, or changes in the amplitudes and kinetics of the intrinsic and synaptic currents within and between the elements making up a network. We argue that the latter changes are often overlooked as sources of alterations in network behavior when there are also structural (connectivity) abnormalities present; indeed, they may even give rise to the structural changes observed in these states. Here we look at two clinically relevant states (Parkinson's disease and schizophrenia) and argue that non-structural changes are important in the development of abnormal dynamics within the networks known to be relevant to each disorder. We also discuss anesthesia, since it is entirely acute, thus illustrating the potent effects of changes in synaptic and intrinsic membrane currents in the absence of structural alteration. In each of these, we focus on the role of changes in GABAergic function within microcircuits, stressing literature within the last few years.

Indexed as

AnesthesiaModels, NeurologicalNonlinear DynamicsAnestheticsgamma-Aminobutyric AcidHumansNerve NetNervous System DiseasesNeuronsAnestheticsgamma-Aminobutyric Acid

Identifiers

PMID22446010
PMCPMC3965179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.