ArticleGender medicine2012
The vasodilatory effect of testosterone on renal afferent arterioles.
Article in Gender medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Trial
- Short-term effects of orchiectomy on the health condition and renal handling of electrolytes in sexually intact adult male cats.Open veterinary journal · 2025Article
- Testosterone therapy is associated with reduced risk of acute kidney injury, kidney failure with renal replacement therapy, and cardiovascular events in men with diabetes and hypogonadism.Cardiovascular diabetology · 2025Observational
- Assessing the impact of resistance training on renal function of female wistar rats under cross-sex hormone therapy.Frontiers in physiology · 2025Article
- [Pituitary disorders in patients with end-stage chronic renal failure].Problemy endokrinologii · 2024Article
- Insights Into the Cardiomodulatory Effects of Sex Hormones: Implications in Transgender Care.Hypertension (Dallas, Tex. : 1979) · 2023Review
- Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome.International journal of molecular sciences · 2021Article
- Androgens, the kidney, and COVID-19: an opportunity for translational research.American journal of physiology. Renal physiology · 2021Article
- NaHCOHypertension (Dallas, Tex. : 1979) · 2019Article
- Novel hemodynamic structures in the human glomerulus.American journal of physiology. Renal physiology · 2018Article
- Glucose dilates renal afferent arterioles via glucose transporter-1.American journal of physiology. Renal physiology · 2018Article
- Enhanced hemodynamic responses to angiotensin II in diabetes are associated with increased expression and activity of AT1 receptors in the afferent arteriole.Physiological genomics · 2017Article
- Is Testosterone Detrimental to Renal Function?Kidney international reports · 2016Article
- Low-dose testosterone protects against renal ischemia-reperfusion injury by increasing renal IL-10-to-TNF-α ratio and attenuating T-cell infiltration.American journal of physiology. Renal physiology · 2016Article
- Overview of Antagonists Used for Determining the Mechanisms of Action Employed by Potential Vasodilators with Their Suggested Signaling Pathways.Molecules (Basel, Switzerland) · 2016Review
- Identification and function of adenosine A3 receptor in afferent arterioles.American journal of physiology. Renal physiology · 2015Article
- Crucial role of androgen receptor in vascular H2S biosynthesis induced by testosterone.British journal of pharmacology · 2015Article
- Low testosterone concentration and atherosclerotic disease markers in male patients with type 2 diabetes.The Journal of clinical endocrinology and metabolism · 2014Article
- Effect of testosterone on Cisplatin-induced nephrotoxicity in surgically castrated rats.Nephro-urology monthly · 2014Article
- Testosterone enhances tubuloglomerular feedback by increasing superoxide production in the macula densa.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSex differences exist in a variety of cardiovascular and renal diseases, and testosterone may contribute to the discrepancy. Afferent arterioles (Af-Arts) are the major resistance vessels in the kidney, and they play an important role in the development of renal injury and hypertension.
objectiveWe sought to determine the acute effect and underlying mechanism(s) of action of testosterone on Af-Arts.
methodsThe mRNA expression of androgen receptors (ARs) in microdissected Af-Arts was measured by reverse transcription-polymerase chain reaction (RT-PCR). An in vitro microperfusion model was used to measure the diameter of Af-Arts in mice. Nitric oxide (NO) was evaluated by an NO-sensitive fluorescent dye, 4-amino-5-methylamino-2',7'-difluorofluorescein diacetate.
resultsTestosterone had no effect on microperfused Af-Arts when added to the bath. Therefore, we preconstricted the Af-Arts to approximately 30% with norepinephrine (10(-6) M); administration of testosterone (10(-9)-10(-7) M) subsequently dilated the Af-Arts in a dose-dependent manner (P < 0.001; n = 7). The AR mRNA was expressed in microdissected Af-Arts measured by RT-PCR. An AR antagonist, flutamide (10(-5) M), totally blocked the testosterone (10(-8) M)-induced vasodilator effect. Mean (SEM) NO production of the Af-Art wall was increased when testosterone was added to the bath solution after norepinephrine treatment, from 278.4 (12.1) U/min to 351.2 (33.1) U/min (P < 0.05; n = 3). In the presence of NO inhibition with N(G)-nitro-L-arginine methyl ester (3 × 10(-4) M), the testosterone-induced dilatation was blunted compared with norepinephrine (P < 0.05).
conclusionsTestosterone dilated preconstricted mouse Af-Arts in a dose-dependent manner by activation of ARs and partially mediated by NO.
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