ArticleInternational journal of radiation oncology, biology, physics2012
Single- and multivoxel proton spectroscopy in pediatric patients with diffuse intrinsic pontine glioma.
Article in International journal of radiation oncology, biology, physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Tumor Response Assessment in Diffuse Intrinsic Pontine Glioma: Comparison of Semiautomated Volumetric, Semiautomated Linear, and Manual Linear Tumor Measurement Strategies.AJNR. American journal of neuroradiology · 2020Trial
- Association between altered metabolism and genetic mutations in human glioma.Cancer reports (Hoboken, N.J.) · 2023Article
- Pediatric Diffuse Midline Gliomas: An Unfinished Puzzle.Diagnostics (Basel, Switzerland) · 2022Review
- Multimodal MR imaging signatures to identify brain diffuse midline gliomas with H3 K27M mutation.Cancer medicine · 2022Article
- Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations.NMR in biomedicine · 2021Article
- Characterization of dysregulated glutamine metabolism in human glioma tissue withScientific reports · 2020Article
- Magnetic resonance spectroscopic imaging in gliomas: clinical diagnosis and radiotherapy planning.BJR open · 2020Review
- Prediction of IDH Status Through MRI Features and Enlightened Reflection on the Delineation of Target Volume in Low-Grade Gliomas.Technology in cancer research & treatment · 2019Article
- The value of magnetic resonance spectroscopy as a supplement to MRI of the brain in a clinical setting.PloS one · 2018Article
- Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging.Contrast media & molecular imaging · 2018Article
- Diffuse intrinsic pontine gliomas-current management and new biologic insights. Is there a glimmer of hope?Neuro-oncology · 2017Review
- Metabolic Imaging in Humans.Topics in magnetic resonance imaging : TMRI · 2016Review
- Discrepant longitudinal volumetric and metabolic evolution of diffuse intrinsic Pontine gliomas during treatment: implications for current response assessment strategies.Neuroradiology · 2016Article
- A Novel Methodology for Applying Multivoxel MR Spectroscopy to Evaluate Convection-Enhanced Drug Delivery in Diffuse Intrinsic Pontine Gliomas.AJNR. American journal of neuroradiology · 2016Article
- Key concepts in MR spectroscopy and practical approaches to gaining biochemical information in children.Pediatric radiology · 2016Review
- Pediatric brainstem gliomas: new understanding leads to potential new treatments for two very different tumors.Current oncology reports · 2015Review
- DIPG in Children - What Can We Learn from the Past?Frontiers in oncology · 2015Review
- Diffuse intrinsic pontine glioma: time for therapeutic optimism.CNS oncology · 2014Review
- Hybrid PET/MR imaging in two sarcoma patients - clinical benefits and implications for future trials.International journal of clinical and experimental medicine · 2014Article
- PET/MR in oncology: an introduction with focus on MR and future perspectives for hybrid imaging.American journal of nuclear medicine and molecular imaging · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo determine the feasibility of two magnetic resonance spectroscopy (MRS) techniques for treating pediatric patients with diffuse intrinsic pontine gliomas (DIPGs) and to evaluate the relationship of metabolic profiles determined by each technique. Utility of each technique for improving patient management is also discussed. METHODS AND MATERIALS: Children with DIPG (n = 36) were evaluated using single-voxel spectroscopy (SVS) and magnetic resonance spectroscopic imaging (MRSI) during the same imaging session. Patients were followed longitudinally (n = 150 total studies). Technical feasibility was defined by sufficient water and lipid suppression for detection of metabolites. Correlation of metabolic data obtained by SVS and MRSI was determined using the Spearman rank method. Metabolite ratios, including choline:N-acetyl-aspartate (Cho:NAA) and Cho:creatine (Cho:Cr), were obtained from SVS and MRSI.
resultsSVS and MRSI acquisitions were feasible in >90% of studies. Maximum Cho:NAA and Cho:Cr from MRSI analysis were strongly associated with Cho:NAA and Cho:Cr obtained by SVS (r = 0.67 and 0.76, respectively). MRSI Cho:NAA values were more heterogeneous than Cho:Cr values within the same lesion, and a strong linear relationship between the range and maximum Cho:NAA values was observed.
conclusionsSVS and MRSI acquisitions were feasible, with a strong correlation in metabolic data. Both techniques may improve diagnostic evaluation and management of DIPG. SVS is recommended for global assessment of tumor metabolism before and after therapy. MRSI showed heterogeneous patterns of metabolic activity within these tumors and is recommended for planning and monitoring targeted therapies and evaluating nearby tissue for tumor invasion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.