ArticleMolecular cell2012
Embryonic stem cells induce pluripotency in somatic cell fusion through biphasic reprogramming.
Article in Molecular cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 54 citations in OpenAlex.
- Human cytomegalovirus exploits host chromatin remodeler MORC2 to promote the DNA damage response on viral genomes.PLoS pathogens · 2026Article
- Cell Fusion in Reprogramming and Regeneration.Advances in experimental medicine and biology · 2026Review
- Genomic Reshuffling After Cell Fusion: Catalyst for Cancer Evolution and Progression.Advances in experimental medicine and biology · 2026Review
- PRMT7: A Pivotal Arginine Methyltransferase in Stem Cells and Development.Stem cells international · 2021Review
- The Master Regulator Protein BAZ2B Can Reprogram Human Hematopoietic Lineage-Committed Progenitors into a Multipotent State.Cell reports · 2020Article
- Alternative dominance of the parental genomes in hybrid cells generated through the fusion of mouse embryonic stem cells with fibroblasts.Scientific reports · 2017Article
- Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis.Scientific reports · 2016Article
- Molecular features of cellular reprogramming and development.Nature reviews. Molecular cell biology · 2016Review
- Induced Pluripotent Stem Cells: Generation Strategy and Epigenetic Mystery behind Reprogramming.Stem cells international · 2016Review
- Cardiac Stem Cell Hybrids Enhance Myocardial Repair.Circulation research · 2015Article
- Circulating around the tissue: hematopoietic cell-based fusion versus transdifferentiation.Circulation research · 2015Article
- Cell divisions are not essential for the direct conversion of fibroblasts into neuronal cells.Cell cycle (Georgetown, Tex.) · 2015Article
- Cell fusion enhances mesendodermal differentiation of human induced pluripotent stem cells.Stem cells and development · 2014Article
- Article
- Molecular control of induced pluripotency.Cell stem cell · 2014Review
- Systematic mapping of occluded genes by cell fusion reveals prevalence and stability of cis-mediated silencing in somatic cells.Genome research · 2014Article
- Article
- Phenotypic changes in growth-arrested T cell hybrids: a possible avenue to produce functional T cell hybridoma.Frontiers in immunology · 2014Review
- Chromatin dynamics during cellular reprogramming.Nature · 2013Review
- Epigenetics of cellular reprogramming.Current opinion in genetics & development · 2013Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
It is a long-held paradigm that cell fusion reprograms gene expression but the extent of reprogramming and whether it is affected by the cell types employed remain unknown. We recently showed that the silencing of somatic genes is attributable to either trans-acting cellular environment or cis-acting chromatin context. Here, we examine how trans- versus cis-silenced genes in a somatic cell type behave in fusions to another somatic cell type or to embryonic stem cells (ESCs). We demonstrate that while reprogramming of trans-silenced somatic genes occurs in both cases, reprogramming of cis-silenced somatic genes occurs only in somatic-ESC fusions. Importantly, ESCs reprogram the somatic genome in two distinct phases: trans-reprogramming occurs rapidly, independent of DNA replication, whereas cis-reprogramming occurs with slow kinetics requiring DNA replication. We also show that pluripotency genes Oct4 and Nanog are cis-silenced in somatic cells. We conclude that cis-reprogramming capacity is a fundamental feature distinguishing ESCs from somatic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.