ArticleThe Journal of surgical research2012
A 9-Year retrospective review of antibiotic cycling in a surgical intensive care unit.
Article in The Journal of surgical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cycling empirical antibiotic therapy in hospitals: meta-analysis and models.PLoS pathogens · 2014Pooled it
- Trial
- Towards evolutionary predictions: Current promises and challenges.Evolutionary applications · 2023Review
- Identification of antibiotic pairs that evade concurrent resistance via a retrospective analysis of antimicrobial susceptibility test results.The Lancet. Microbe · 2021Article
- Assessment of Awareness about Antibiotic Resistance and Practices Followed by Veterinarians for Judicious Prescription of Antibiotics: An Exploratory Study in Eastern Haryana Region of India.Tropical animal health and production · 2019Article
- Effects of Antibiotic Cycling Policy on Incidence of Healthcare-Associated MRSA and Clostridioides difficile Infection in Secondary Healthcare Settings.Emerging infectious diseases · 2019Article
- Drug-mediated metabolic tipping between antibiotic resistant states in a mixed-species community.Nature ecology & evolution · 2018Article
- Ecological effects of cefepime use during antibiotic cycling on the Gram-negative enteric flora of ICU patients.Intensive care medicine experimental · 2018Article
- Modeling antibiotic treatment in hospitals: A systematic approach shows benefits of combination therapy over cycling, mixing, and mono-drug therapies.PLoS computational biology · 2017Article
- History of antibiotic adaptation influences microbial evolutionary dynamics during subsequent treatment.PLoS biology · 2017Article
- A Review of Quality Measures for Assessing the Impact of Antimicrobial Stewardship Programs in Hospitals.Antibiotics (Basel, Switzerland) · 2016Review
- Article
- Temporal variation in antibiotic environments slows down resistance evolution in pathogenic Pseudomonas aeruginosa.Evolutionary applications · 2015Article
- Antibiotic stewardship programmes in intensive care units: Why, how, and where are they leading us.World journal of critical care medicine · 2015Review
- Controlling resistant bacteria with a novel class of β-lactamase inhibitor peptides: from rational design to in vivo analyses.Scientific reports · 2014Article
- Strategies to minimize antibiotic resistance.International journal of environmental research and public health · 2013Review
- Designing antibiotic cycling strategies by determining and understanding local adaptive landscapes.PloS one · 2013Article
- Article
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Abstract
backgroundSix years after initiating a monthly antibiotic cycling protocol in the surgical intensive care unit (SICU), we retrospectively reviewed antibiogram-derived sensitivities of predominant gram-negative pathogens before and after antibiotic cycling. We also examined susceptibility patterns in the medical intensive care unit (MICU) where antibiotic cycling is not practiced. MATERIALS AND
methodsAntibiotic cycling protocol was implemented in the SICU starting in 2003, with monthly rotation of piperacillin/tazobactam, imipenem/cilastin, and ceftazidime. SICU antibiogram data from positive clinical cultures for years 2000 and 2002 were included in the pre-cycling period, and those from 2004 to 2009 in the cycling period.
resultsProfiles of SICU pseudomonal isolates before (n = 116) and after (n = 205) implementing antibiotic cycling showed statistically significant improvements in susceptibility to ceftazidime (66% versus 81%; P = 0.003) and piperacillin/tazobactam (75% versus 85%; P = 0.021), while susceptibility to imipenem remained unaltered (70% in each case; P = 0.989). Susceptibility of E. coli isolates to piperacillin/tazobactam improved significantly (46% versus 83%; P < 0.0005), trend analysis showing this improvement to persist over the study period (P = 0.025). Similar findings were not observed in the MICU. Review of 2004-2009 antibiotic prescription practices showed monthly heterogeneity in the SICU, and a 2-fold higher prescribing of piperacillin/tazobactam in the MICU (P < 0.0001).
conclusionsSix years into antibiotic cycling, we found either steady or improved susceptibilities of clinically relevant gram-negative organisms in the SICU. How much of this effect is from cycling is unknown, but the antibiotic heterogeneity provided by this practice justifies its ongoing use.
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