ArticleNeuron2012
Disintegrating brain networks: from syndromes to molecular nexopathies.
Article in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03939286 (Multimodal Imaging Study on Physical Activity in Patients With Alzheimer's Disease), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multimodal Imaging Study on Physical Activity in Patients With Alzheimer's Disease
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Hubs of long-distance co-alteration characterize brain pathology.Human brain mapping · 2020Pooled it
- Conceptualizing neuropsychiatric diseases with multimodal data-driven meta-analyses - the case of behavioral variant frontotemporal dementia.Cortex; a journal devoted to the study of the nervous system and behavior · 2014Pooled it
- Disruption of macroscale functional network organisation in patients with frontotemporal dementia.Molecular psychiatry · 2025Article
- Cross-sectional and Longitudinal Age-related Disintegration in Functional Connectivity: Reference Ability Neural Network Cohort.Journal of cognitive neuroscience · 2024Article
- Observational
- Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia.Brain : a journal of neurology · 2023Article
- Altered structural brain networks in linguistic variants of frontotemporal dementia.Brain imaging and behavior · 2022Article
- Structural alterations of the insula in depression patients - A 7-Tesla-MRI study.NeuroImage. Clinical · 2022Article
- Graph Models of Pathology Spread in Alzheimer's Disease: An Alternative to Conventional Graph Theoretic Analysis.Brain connectivity · 2021Review
- Age-related disintegration in functional connectivity: Evidence from Reference Ability Neural Network (RANN) cohort.Neuropsychologia · 2021Article
- Dystonia Management: What to Expect From the Future? The Perspectives of Patients and Clinicians Within DystoniaNet Europe.Frontiers in neurology · 2021Review
- Functional Characterization of Atrophy Patterns Related to Cognitive Impairment.Frontiers in neurology · 2020Article
- Vulnerability of multiple large-scale brain networks in dementia with Lewy bodies.Human brain mapping · 2019Article
- The inner fluctuations of the brain in presymptomatic Frontotemporal Dementia: The chronnectome fingerprint.NeuroImage · 2019Article
- Unraveling connectivity changes due to dopaminergic therapy in chronically treated Parkinson's disease patients.Scientific reports · 2018Article
- Brain connectivity changes when comparing effects of subthalamic deep brain stimulation with levodopa treatment in Parkinson's disease.NeuroImage. Clinical · 2018Article
- Topographic Markers Drive Proteinopathies to Selection of Target Brain Areas at Onset in Neurodegenerative Dementias.Frontiers in aging neuroscience · 2018Article
- Altered brain metabolic connectivity at multiscale level in early Parkinson's disease.Scientific reports · 2017Article
- Article
- Frontomedian cortex is central for moral deficits in behavioural variant frontotemporal dementia.Journal of neurology, neurosurgery, and psychiatry · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In this issue of Neuron, Raj et al. (2012) and Zhou et al. (2012) use graph theory to suggest that neurodegenerative diseases spread diffusively via intrinsic brain networks. These studies provide a powerful model for understanding and predicting disease-specific profiles of neurodegeneration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.