Trial reportSleep medicine2012
Laboratory validation of an in-home method for assessing circadian phase using dim light melatonin onset (DLMO).
Trial report in Sleep medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Early chronotype with advanced activity rhythms and dim light melatonin onset in a rural population.Journal of pineal research · 2020Trial
- Home Circadian Phase Assessments with Measures of Compliance Yield Accurate Dim Light Melatonin Onsets.Sleep · 2015Trial
- "Like Taking Part in Star Wars": Qualitative Study Using Thematic Analysis to Explore the Acceptability and Experiences of Older Adults Participating in Remote Longitudinal Sleep and Dementia Research.Journal of medical Internet research · 2026Article
- A gradual and sustainable approach to diagnosing sleep and circadian disturbances in dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- An Assessment of Melatonin Levels in the Saliva of Patients with Chronic Urticaria in Comparison with Their Sleep Quality and Dermatologic Quality of Life.Clinics and practice · 2026Article
- Adolescent circadian sleep health: a review of multimodal assessment strategies and clinical implications.Frontiers in sleep · 2026Review
- Feasibility of a contactless, self-directed, home-based dim-light melatonin onset protocol: the Circadia pilot study.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Methods for Assessment of Sleep and Circadian Rhythms in Cardiovascular Research.Current hypertension reports · 2025Review
- The rhythm of decline: Circadian disruption in neurodegeneration.Journal of food and drug analysis · 2025Review
- Circadian Biomarkers in Humans: Methodological Insights into the Detection of Melatonin and Cortisol.Biomolecules · 2025Review
- No association between chronotype and cardiovascular response to a cognitive challenge in the morning using a Bayesian approach.Neurobiology of sleep and circadian rhythms · 2025Article
- Home-based dim light melatonin onset assessment among adults with obesity: feasibility and procedural considerations.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Integrating Assessment of Circadian Rhythmicity to Improve Treatment Outcomes for Circadian Rhythm Sleep-Wake Disorders: Updates on New Treatments.Current sleep medicine reports · 2025Review
- A pre-post trial to examine biological mechanisms of the effects of time-restricted eating on symptoms and quality of life in bipolar disorder.BMC psychiatry · 2024Article
- Circadian protein expression patterns in healthy young adults.Sleep health · 2024Article
- Unraveling the interplay of circadian rhythm and sleep deprivation on mood: A Real-World Study on first-year physicians.PLOS digital health · 2024Article
- Behavioural Parameters of Circadian Rhythm Are Not Correlated with Dim Light Melatonin Onset: An Observational Study on Healthy Volunteers.Journal of clinical medicine · 2023Article
- The Timing of the Melatonin Onset and Phase Angle to Sleep Onset in Older Adults after Uncontrolled vs. Controlled Lighting Conditions.Clocks & sleep · 2023Article
- Article
- Intake of L-serine before bedtime prevents the delay of the circadian phase in real life.Journal of physiological anthropology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveTo determine whether an accurate circadian phase assessment could be obtained from saliva samples collected by patients in their home.
methodsTwenty-four individuals with a complaint of sleep initiation or sleep maintenance difficulty were studied for two evenings. Each participant received instructions for collecting eight hourly saliva samples in dim light at home. On the following evening they spent 9h in a laboratory room with controlled dim (<20 lux) light where hourly saliva samples were collected. Circadian phase of dim light melatonin onset (DLMO) was determined using both an absolute threshold (3 pg ml(-1)) and a relative threshold (two standard deviations above the mean of three baseline values).
resultsNeither threshold method worked well for one participant who was a "low-secretor". In four cases the participants' in-lab melatonin levels rose much earlier or were much higher than their at-home levels, and one participant appeared to take the at home samples out of order. Overall, the at-home and in-lab DLMO values were significantly correlated using both methods, and differed on average by 37 (± 19)min using the absolute threshold and by 54 (± 36)min using the relative threshold.
conclusionsThe at-home assessment procedure was able to determine an accurate DLMO using an absolute threshold in 62.5% of the participants. Thus, an at-home procedure for assessing circadian phase could be practical for evaluating patients for circadian rhythm sleep disorders.
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