ArticleCurrent biology : CB2012
Free extracellular diffusion creates the Dpp morphogen gradient of the Drosophila wing disc.
Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed.
- Characterization and modeling of the borate transporter BOR3 suggest a mode of directional transport.Plant physiology · 2026Article
- Cellular mechanometabolism: stimuli and implications.EMBO reports · 2026Review
- Shaping and interpretation of Dpp morphogen gradient by endocytic trafficking.PLoS genetics · 2025Article
- Receptor binding and tortuosity explain morphogen local-to-global diffusion coefficient transition.Biophysical journal · 2025Article
- Fine-tuning of Fgf8 morphogen gradient by heparan sulfate proteoglycans in the extracellular matrix.Biophysical journal · 2025Article
- Digital cousins: Simultaneous optimization of one model for BMP signaling in distant relatives reveals essential core.Computational and structural biotechnology journal · 2025Article
- Dynamics of BMP signaling and stable gene expression in the early Drosophila embryo.Biology open · 2024Article
- Understanding and manipulating extracellular behaviors of Wnt ligands.In vitro cellular & developmental biology. Animal · 2024Review
- Long-range formation of the Bicoid gradient requires multiple dynamic modes that spatially vary across the embryo.Development (Cambridge, England) · 2024Article
- Real-time monitoring of an endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation.Development (Cambridge, England) · 2023Article
- Reconstitution of morphogen shuttling circuits.Science advances · 2023Article
- Current capabilities and future perspectives of FCS: super-resolution microscopy, machine learning, and in vivo applications.Communications biology · 2023Review
- A multiscale chemical-mechanical model predicts impact of morphogen spreading on tissue growth.NPJ systems biology and applications · 2023Article
- A chemo-mechanical model of endoderm movements driving elongation of the amniote hindgut.bioRxiv : the preprint server for biology · 2023Article
- Autocorrelation function of finite-length data in fluorescence correlation spectroscopy.Biophysical journal · 2023Article
- Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model.Nature communications · 2022Article
- Patterning principles of morphogen gradients.Open biology · 2022Review
- Fixation of Embryonic Mouse Tissue for Cytoneme Analysis.Journal of visualized experiments : JoVE · 2022Article
- The wing imaginal disc.Genetics · 2022Article
- Article
22 more citing papers are in PubMed but not listed here.
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7 authors.
Funding
Abstract
backgroundHow morphogen gradients form has long been a subject of controversy. The strongest support for the view that morphogens do not simply spread by free diffusion has come from a variety of studies of the Decapentaplegic (Dpp) gradient of the Drosophila larval wing disc.
resultsIn the present study, we initially show how the failure, in such studies, to consider the coupling of transport to receptor-mediated uptake and degradation has led to estimates of transport rates that are orders of magnitude too low, lending unwarranted support to a variety of hypothetical mechanisms, such as "planar transcytosis" and "restricted extracellular diffusion." Using several independent dynamic methods, we obtain data that are inconsistent with such models and show directly that Dpp transport occurs by simple, rapid diffusion in the extracellular space. We discuss the implications of these findings for other morphogen systems in which complex transport mechanisms have been proposed.
conclusionsWe believe that these findings resolve a major, longstanding question about morphogen gradient formation and provide a solid framework for interpreting experimental observations of morphogen gradient dynamics.
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