ArticleTrends in biochemical sciences2012
Undecided membrane proteins insert in random topologies. Up, down and sideways: it does not really matter.
Article in Trends in biochemical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Medicinal Plants: A Promising Therapeutic Approach for Addressing Antimicrobial Resistance.International journal of molecular sciences · 2026Review
- Bacterial Resistance to Antimicrobial Agents.Antibiotics (Basel, Switzerland) · 2021Review
- Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.Chemical reviews · 2021Review
- SAXS analysis of a soluble cytosolic NgBR construct including extracellular and transmembrane domains.PloS one · 2018Article
- Stable membrane orientations of small dual-topology membrane proteins.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Effects of mixed proximal and distal topogenic signals on the topological sensitivity of a membrane protein to the lipid environment.Biochimica et biophysica acta. Biomembranes · 2017Article
- Metabolism of Free Guanidine in Bacteria Is Regulated by a Widespread Riboswitch Class.Molecular cell · 2017Article
- In vitro membrane protein synthesis inside Sec translocon-reconstituted cell-sized liposomes.Scientific reports · 2016Article
- The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.Clinical microbiology reviews · 2015Review
- Ligand-induced conformational changes of the multidrug resistance transporter EmrE probed by oriented solid-state NMR spectroscopy.Angewandte Chemie (International ed. in English) · 2013Article
- Article
- Lipid-dependent generation of dual topology for a membrane protein.The Journal of biological chemistry · 2012Article
- Transforming a drug/H+ antiporter into a polyamine importer by a single mutation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Role of protons in sugar binding to LacY.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Antiparallel dimers of the small multidrug resistance protein EmrE are more stable than parallel dimers.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
It is usually assumed that to ensure proper function, membrane proteins must be inserted in a unique topology. However, a number of dimeric small multidrug transporters can function in the membrane in various topologies. Thus, the dimers can be a random mixture of NiCi (N and C termini facing the cell cytoplasm) and NoCo (N and C termini facing the outside) orientation. In addition, the dimer functions whether the two protomers are parallel (N and C termini of both protomers on the same side of the membrane) or antiparallel (N and C termini of each protomer on opposite sides of the membrane). This unique phenomenon provides strong support for a simple mechanism of transport where the directionality is determined solely by the driving force.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.