Evidence map›Paper›PMID 22444728›Full record

ReviewTrends in cell biology2012

Endocytic trafficking of neurotrophins in neural development.

Maria Ascano, Daniel Bodmer, Rejji Kuruvilla

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Trial
  2. Article
  3. AFrontiers in genetics · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Long-distance regressive signaling in neural development and disease.Wiley interdisciplinary reviews. Developmental biology · 2021
    Review
  12. The development of somatosensory neurons: Insights into pain and itch.Current topics in developmental biology · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maria AscanoDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.
Daniel Bodmer
Rejji Kuruvilla

Funding

Neurotrophin mechanisms in neural development and diseaseR01NS073751 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KURUVILLA, REJJI · 2011 to 2015
$1.7M
Crosstalk between neurotrophin and Wnt signaling pathways in neuronal developmentR01MH080738 · NIMH · JOHNS HOPKINS UNIVERSITY · PI KURUVILLA, REJJI · 2007 to 2011
$1.5M
Neurotrophins in Pancreas DevelopmentR21DK090624 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI KURUVILLA, REJJI · 2011 to 2012
$444k
NIDDK NIH HHS R21 DK090624NIDDK NIH HHS R21DK090624NIMH NIH HHS R01 MH080738NIMH NIH HHS R01MH080738NINDS NIH HHS R01 NS073751NINDS NIH HHS R01NS073751
6 · The paper itself

Abstract

During the formation of neuronal circuits, neurons respond to diffusible cues secreted by target tissues. Often, target-derived signals act on nerve terminals to influence local growth events; in other cases, they are transported long distances back to neuronal cell bodies to effect transcriptional changes necessary for neuronal survival and differentiation. Neurotrophins provide one of the best examples of target-derived cues that elicit an astonishingly diverse array of neuronal responses. Endocytic trafficking of neurotrophins and their receptors is a fundamental feature of neurotrophin signaling, allowing neurotrophins to control neuronal survival by retrograde transport of signaling endosomes containing ligand-receptor complexes. In this review we summarize recent findings that provide new insight into the interplay between neurotrophin signaling and trafficking.

Indexed as

AnimalsApoptosisEndosomesHumansNerve Growth FactorsNeuronsProtein TransportSignal TransductionNerve Growth Factors

Identifiers

PMID22444728
PMCPMC3348440

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.