ReviewCurrent opinion in biotechnology2012
Tissue engineering 2.0: guiding self-organization during pluripotent stem cell differentiation.
Review in Current opinion in biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Bioengineering Strategies to Create 3D Cardiac Constructs from Human Induced Pluripotent Stem Cells.Bioengineering (Basel, Switzerland) · 2022Review
- Recapitulating pancreatic cell-cell interactions through bioengineering approaches: the momentous role of non-epithelial cells for diabetes cell therapy.Cellular and molecular life sciences : CMLS · 2021Review
- Cellular Fragments as Biomaterial for Rapid In Vitro Bone-Like Tissue Synthesis.International journal of molecular sciences · 2020Article
- Building Complex Life Through Self-Organization.Tissue engineering. Part A · 2019Review
- Review
- Neural Differentiation of Spheroids Derived from Human Induced Pluripotent Stem Cells-Mesenchymal Stem Cells Coculture.Tissue engineering. Part A · 2018Article
- Article
- Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy.ACS applied materials & interfaces · 2017Article
- From Reductionism to Holism: Toward a More Complete View of Development Through Genome Engineering.Advances in experimental medicine and biology · 2017Review
- Microfluidic systems for stem cell-based neural tissue engineering.Lab on a chip · 2016Review
- Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids.Integrative biology : quantitative biosciences from nano to macro · 2016Review
- Multiscale assembly for tissue engineering and regenerative medicine.Trends in biotechnology · 2015Review
- Human pluripotent stem cell-derived retinal pigmented epithelium in retinal treatment: from bench to bedside.Molecular neurobiology · 2014Review
- Engineering liver.Hepatology (Baltimore, Md.) · 2014Review
- Localized cell death focuses mechanical forces during 3D patterning in a biofilm.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- In vitro organogenesis from pluripotent stem cells.OrganogenesisReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Human pluripotent stem cell (hPSC) differentiation aims to mimic development using growth factors or small molecules in a time-dependent and dose-dependent manner. However, the cell types produced using this approach are predominantly fetal-like in phenotype and function, limiting their use in regenerative medicine. This is particularly true in current efforts to produce pancreatic beta cells, wherein robust pancreatic progenitor maturation can only be accomplished upon transplantation into mice. Recent studies have suggested that hPSC-derived cells are capable of self-organizing in vitro, revealing a new paradigm for creating mature cells and tissues. Tissue engineering strategies that provide subtle and dynamic signals to developmentally naïve cells may be applied to mimic in vitro the self-organization aspects of pancreatic development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.