Evidence map›Paper›PMID 22444145›Full record

ReviewMethods in cell biology2012

Conservation and innovation in Tetrahymena membrane traffic: proteins, lipids, and compartments.

Alejandro D Nusblat, Lydia J Bright, Aaron P Turkewitz

Abstract readReview
In one paragraph

Review in Methods in cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Therapeutic Antibodies Targeting Potassium Ion Channels.Handbook of experimental pharmacology · 2021
    Article
  6. Article
  7. Article
  8. Review
  9. Inseparable tandem: evolution chooses ATP and Ca2+ to control life, death and cellular signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016
    Review
  10. Tetrahymena thermophila: a divergent perspective on membrane traffic.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2014
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alejandro D NusblatCátedra de Biotecnología y Microbiología Industrial, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, (C1113AAD) Buenos Aires, Argentina.
Lydia J Bright
Aaron P Turkewitz

Funding

PREDOCTORAL TRAINING IN GENETICS AND REGULATIONT32GM007197 · NIGMS · UNIVERSITY OF CHICAGO · PI ROTHMAN-DENES, LUCIA B. B · 1985 to 2020
$17.0M
Biogenesis of Dense Core Secretory Granules in TetrahymenaR01GM077607 · NIGMS · UNIVERSITY OF CHICAGO · PI TURKEWITZ, AARON P · 2006 to 2009
$1.1M
NIGMS NIH HHS GM077607NIGMS NIH HHS R01 GM077607NIGMS NIH HHS T32 GM007197
6 · The paper itself

Abstract

The past decade has seen a significant expansion in our understanding of membrane traffic in Tetrahymena thermophila, facilitated by the development of new experimental tools and by the availability of the macronuclear genome sequence. Here we review studies on multiple pathways of uptake and secretion, as well as work on metabolism of membrane lipids. We discuss evidence for conservation versus innovation in the mechanisms used in ciliates compared with those in other eukaryotic lineages, and raise the possibility that existing gene expression databases can be exploited to analyze specific pathways of membrane traffic in these cells.

Indexed as

Genes, ProtozoanBiomarkersCell MembraneDynaminsMembrane LipidsMembrane ProteinsPhagocytosisPhagosomesProtein TransportProteomeProtozoan Proteinsrab GTP-Binding ProteinsSpecies SpecificityTetrahymena thermophilaBiomarkersDynaminsMembrane LipidsMembrane ProteinsProteomeProtozoan Proteinsrab GTP-Binding Proteins

Identifiers

PMID22444145
PMCPMC4711351

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.