Trial reportPloS one2012
Women with endometriosis are more likely to suffer from migraines: a population-based study.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Immune System, Inflammation, Migraine - The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology
Investigating the inFluence of EndoMetriosis IN migraINE - FEMININE Study
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- The association between endometriosis and migraine: a systematic review and meta-analysis of observational studies.The journal of headache and pain · 2025Pooled it
- Central changes associated with chronic pelvic pain and endometriosis.Human reproduction updatePooled it
- Predictive markers of endometriosis: a future perspective.Archives of gynecology and obstetrics · 2026Review
- Prevalence of migraine subtypes in women with endometriosis and/or dysmenorrhea: results from a cross-sectional multicenter trial.BMC women's health · 2026Article
- Citizen science reveals comorbidities in endometriosis with no shift in vaginal microbiome composition.npj women's health · 2026Article
- A Correlation Between Migraine and Endometriosis and Its Clinical Implications-A Systematic Literature Review.Journal of clinical medicine · 2025Review
- Prolactin-induced sensitization of trigeminal nociceptors promotes migraine co-morbidity in endometriosis.Cephalalgia : an international journal of headache · 2025Article
- Endometriosis, Raynaud's Syndrome, and Migraine: A Retrospective Study of 12 Million Women.Gynecologic and obstetric investigation · 2025Article
- Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis.Nature communications · 2024Article
- Investigating migraine phenotype and dynamics in women with endometriosis: an observational pilot study.Acta neurologica Belgica · 2024Observational
- Migraine among women with endometriosis: a hospital-based case-control study in Bangladesh.AJOG global reports · 2024Article
- Considerations for hormonal therapy in migraine patients: a critical review of current practice.Expert review of neurotherapeutics · 2023Review
- Insights from Mendelian randomization and genetic correlation analyses into the relationship between endometriosis and its comorbidities.Human reproduction update · 2023Review
- Genomic characterisation of the overlap of endometriosis with 76 comorbidities identifies pleiotropic and causal mechanisms underlying disease risk.Human genetics · 2023Article
- Gastroenterologist Primer: Endometriosis for Gastroenterologists.Digestive diseases and sciences · 2023Review
- Relationships between headache frequency, disability, and disability-related unemployment among adults with migraine.Journal of managed care & specialty pharmacy · 2023Article
- Living with endometriosis: Comorbid pain disorders, characteristics of pain and relevance for daily life.European journal of pain (London, England) · 2022Article
- Insights from genomic studies on the role of sex steroids in the aetiology of endometriosis.Reproduction & fertility · 2022Review
- Article
- Ibero-American Endometriosis Patient Phenome: Demographics, Obstetric-Gynecologic Traits, and Symptomatology.Frontiers in reproductive health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous research suggests that a co-morbid relationship exists between migraine and endometriosis; however, results have been inconsistent. In addition, female hormones, which are important in the pathogenesis and management of endometriosis, have been reported to precipitate migraine attacks and may confound the results. The aim of this population-based cohort study was to explore the relationship between migraine and endometriosis in women of reproductive age (18-51 years). Data were derived from the National Health Insurance Research Database of Taiwan, which contains outpatient and inpatient records from 2000 to 2007. Our study cohort included 20,220 endometriosis patients and 263,767 controls without endometriosis. We analyzed the prevalence of migraine in these women as recorded during the eight years of the database. Our results found that patients with endometriosis were more likely to suffer migraine headaches compared to controls (odds ratio [OR], 1.70; 95% confidence interval [CI] [1.59, 1.82]; p<0.001). In addition, the co-morbid association between migraine and endometriosis remained significant after the data were controlled for age and frequently utilized hormone therapies (OR, 1.37; 95% CI, [1.27, 1.47]; p<0.001). The results of this cohort study support the existence of a co-morbid relationship between migraine and endometriosis, even after adjusting for the possible effects of female hormone therapies on migraine attacks.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.