Trial reportPloS one2012
Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Zinc-alpha2-glycoprotein, dysglycaemia and insulin resistance: a systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2020Pooled it
- Identification of potential salivary biomarker panels for oral squamous cell carcinoma.Scientific reports · 2021Trial
- Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor Increases Circulating Zinc-Α2-Glycoprotein Levels in Patients with Type 2 Diabetes.Scientific reports · 2016Trial
- Transdermal self-assembled Xanthine/hybrid needle nanofibers for management of abdominal obesity via phosphodiesterase 4B suppression.Molecular diversity · 2026Article
- Zinc and Adipose Organ Dysfunction: Molecular Insights into Obesity and Metabolic Disorders.Current nutrition reports · 2025Review
- Changes in the Protein Profile of Saliva from People with Obesity Treated with Bariatric Surgery and Physical Exercise.International journal of molecular sciences · 2025Article
- Genetic and epigenetic alterations in night shift nurses with breast cancer: a narrative review.Cancer cell international · 2025Review
- ZAG (Zinc-Alpha 2 Glycoprotein) Serum Levels in Girls with Anorexia Nervosa.Journal of clinical medicine · 2023Article
- Genome-wide association study reveals genetic loci and candidate genes for meat quality traits in a four-way crossbred pig population.Frontiers in genetics · 2023Article
- Article
- Zinc.Advances in food and nutrition research · 2021Review
- The relationship between serum adipokines and glucose homeostasis in normal-weight and obese patients on hemodialysis: a preliminary study.International urology and nephrology · 2020Article
- Zinc-α2-glycoprotein as an inhibitor of amine oxidase copper-containing 3.Open biology · 2020Article
- Serum ZAG and Adiponectin Levels Were Closely Related to Obesity and the Metabolically Abnormal Phenotype in Chinese Population.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism.The journal of physiological sciences : JPS · 2018Review
- Zinc-α2-Glycoprotein Is Associated with Obesity in Chinese People and HFD-Induced Obese Mice.Frontiers in physiology · 2018Article
- Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes.Diabetes · 2017Article
- Response to Letter to the Editor: Systemic Adiponectin Values in Humans Require Standardized Units.Obesity surgery · 2016Article
- The expression of genes involved in jejunal lipogenesis and lipoprotein synthesis is altered in morbidly obese subjects with insulin resistance.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue.Journal of translational medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveZinc-α(2) glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. However, to date no studies have been made in the most extreme of obesity. The aims of this study are to analyze ZAG expression levels in adipose tissue from morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR).
methodsmRNA expression levels of PPARγ, IRS-1, IRS-2, lipogenic and lipolytic genes and ZAG were quantified in visceral (VAT) and subcutaneous adipose tissue (SAT) of 25 nondiabetic morbidly obese patients, 11 with low IR and 14 with high IR. Plasma ZAG was also analyzed.
resultsThe morbidly obese patients with low IR had a higher VAT ZAG expression as compared with the patients with high IR (p = 0.023). In the patients with low IR, the VAT ZAG expression was greater than that in SAT (p = 0.009). ZAG expression correlated between SAT and VAT (r = 0.709, p<0.001). VAT ZAG expression was mainly predicted by insulin, HOMA-IR, plasma adiponectin and expression of adiponectin and ACSS2. SAT ZAG expression was only predicted by expression of ATGL.
conclusionsZAG could be involved in modulating lipid metabolism in adipose tissue and is associated with insulin resistance. These findings suggest that ZAG may be a useful target in obesity and related disorders, such as diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.