ArticleNational journal of maxillofacial surgery2011
Expression of p53 protein and ki-67 antigen in oral premalignant lesions and oral squamous cell carcinomas: An immunohistochemical study.
Article in National journal of maxillofacial surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 78 citations in OpenAlex.
- The oral microbiota in oral squamous cell carcinoma: unravelling mechanisms and clinical potential.Cancer cell international · 2026Review
- Immunological Analysis of Oral Cytobrush Specimens for Early Detection of Oral Cancer Biomarkers: A Comprehensive Review.International journal of molecular sciences · 2026Review
- Article
- P53 and Ki67 Biomarkers are Predictors for Malignant Transformation in Oral Submucous Fibrosis: A Prospective Study.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Potential Immunohistochemical Biomarkers for Grading Oral Dysplasia: A Literature Review.Biomedicines · 2024Review
- OralImmunoAnalyser: a software tool for immunohistochemical assessment of oral leukoplakia using image segmentation and classification models.Frontiers in artificial intelligence · 2024Article
- Article
- Investigating the factors proposed in oral lichen planus malignant transformation: A literature review.Health science reports · 2023Article
- Oral Submucous Fibrosis: Etiological Mechanism, Malignant Transformation, Therapeutic Approaches and Targets.International journal of molecular sciences · 2023Review
- Predictive value of tissue p53 protein expression and serum p53 antibodies in oral potentially malignant disorders: Relative to oral squamous cell carcinoma.Journal of Taibah University Medical Sciences · 2022Article
- Expression of Ki67 Biomarker in Oral Submucous Fibrosis with Clinico-Pathological Correlations: A Prospective Study.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- IMP3 Immunohistochemical Expression in Inverted Papilloma and Inverted Papilloma-Associated Sinonasal Squamous Cell Carcinoma.Analytical cellular pathology (Amsterdam) · 2021Article
- Importance of Ki-67 Labeling in Oral Leukoplakia with Features of Dysplasia and Carcinomatous Transformation: An Observational Study over 4 Years.South Asian journal of cancer · 2020Article
- A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis.International journal of experimental pathology · 2020Article
- Expression of Ki-67 and Βeta-Catenin in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma in Oral Mucosal Biopsies : An Immunohistochemical Study.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Analysis of Ki-67 Expression in Oral Premalignant Lesions and Normal Oral Mucosa: An Immunohistochemical Study.Journal of pharmacy & bioallied sciences · 2019Article
- Immunohistochemical Study of p53 Expression in Patients with Erosive and Non-Erosive Oral Lichen Planus.Journal of dentistry (Shiraz, Iran) · 2018Article
- Markers of Oral Lichen Planus Malignant Transformation.Disease markers · 2018Review
- Observational
- Assesment of Correlation of Herpes Simplex Virus-1 with Oral Cancer and Precancer- A Comparative Study.Journal of clinical and diagnostic research : JCDR · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study expression of p53 protein and ki-67 antigen in normal, non-dysplastic, dysplastic, premalignant and malignant lesions of the oral mucosa. MATERIALS AND
methodsThe standard immunohistochemical method along with MIB-1 and DO-7; DAKO antibodies was used to study the expression of p53 and ki-67 in paraffin-embedded tissue specimens.
resultsAll samples studied showed positive staining for p53 and ki-67. Only one case each from leukoplakia and oral squamous cell carcinoma (OSCC) groups showed negative staining for ki-67. The staining was confined to basal layer in most of the cases except OSCC in which it was seen in all layers. The intensity of staining was moderate to intense. The percentage of p53-positive cells in normal mucosa was 15-25% which was increased to 95% in malignant mucosa. Statistical analysis revealed that the expression of p53 and ki-67 increases as normal oral mucosa becomes dysplastic and undergoes malignant transformation.
conclusionThese results emphasize the potential use of p53 protein and ki-67 antigen as markers of malignant transformation and carcinogenesis in oral premalignant lesions, conditions and OSCC, respectively; and in future they may serve as prognostic tools in the early detection of malignant transformation in oral premalignant lesions and conditions.
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