ArticleJournal of neurophysiology2012
Functional characterization of dI6 interneurons in the neonatal mouse spinal cord.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery.JOR spine · 2025Review
- In vitro longitudinal lumbar spinal cord preparations to study sensory and recurrent motor microcircuits of juvenile mice.Journal of neurophysiology · 2022Article
- Identification of adult spinal Shox2 neuronal subpopulations based on unbiased computational clustering of electrophysiological properties.Frontiers in neural circuits · 2022Article
- Unusual Quadrupedal Locomotion in Rat during Recovery from Lumbar Spinal Blockade of 5-HTInternational journal of molecular sciences · 2021Article
- Spinal Inhibitory Interneurons: Gatekeepers of Sensorimotor Pathways.International journal of molecular sciences · 2021Review
- Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression.Molecular brain · 2020Article
- The mammalian spinal commissural system: properties and functions.Journal of neurophysiology · 2020Review
- The rhythm section: An update on spinal interneurons setting the beat for mammalian locomotion.Current opinion in physiology · 2019Article
- Characterization of Dmrt3-Derived Neurons Suggest a Role within Locomotor Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Mapping Connectivity Amongst Interneuronal Components of the Locomotor CPG.Frontiers in cellular neuroscience · 2019Article
- Sub-populations of Spinal V3 Interneurons Form Focal Modules of Layered Pre-motor Microcircuits.Cell reports · 2018Article
- Neuron-specific inactivation ofLife science alliance · 2018Article
- Diversity of molecularly defined spinal interneurons engaged in mammalian locomotor pattern generation.Journal of neurophysiology · 2017Review
- Delineating the Diversity of Spinal Interneurons in Locomotor Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Stem cells for spinal cord injury: Strategies to inform differentiation and transplantation.Biotechnology and bioengineering · 2017Review
- Central control of interlimb coordination and speed-dependent gait expression in quadrupeds.The Journal of physiology · 2016Article
- Making sense out of spinal cord somatosensory development.Development (Cambridge, England) · 2016Review
- Review
- Peeling back the layers of locomotor control in the spinal cord.Current opinion in neurobiology · 2015Review
- Sensory-evoked perturbations of locomotor activity by sparse sensory input: a computational study.Journal of neurophysiology · 2015Article
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Authors and funding
3 authors.
Funding
Abstract
Our understanding of the neural control of locomotion has been greatly enhanced by the ability to identify and manipulate genetically defined populations of interneurons that comprise the locomotor central pattern generator (CPG). To date, the dI6 interneurons are one of the few populations that settle in the ventral region of the postnatal spinal cord that have not been investigated. In the present study, we utilized a novel transgenic mouse line to electrophysiologically characterize dI6 interneurons located close to the central canal and study their function during fictive locomotion. The majority of dI6 cells investigated were found to be rhythmically active during fictive locomotion and could be divided into two electrophysiologically distinct populations of interneurons. The first population fired rhythmic trains of action potentials that were loosely coupled to ventral root output and contained several intrinsic membrane properties of rhythm-generating neurons, raising the possibility that these cells may be involved in the generation of rhythmic activity in the locomotor CPG. The second population fired rhythmic trains of action potentials that were tightly coupled to ventral root output and lacked intrinsic oscillatory mechanisms, indicating that these neurons may be driven by a rhythm-generating network. Together these results indicate that dI6 neurons comprise an important component of the locomotor CPG that participate in multiple facets of motor behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.