SynthesisNeurology2012
No consistent evidence for association between mtDNA variants and Alzheimer disease.
Synthesis in Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Nuclear genetic modulation of tissue-specific mitochondrial RNA processing contributes to common disease risk.Nature communications · 2026Article
- Precision mitochondrial medicine.Cambridge prisms. Precision medicine · 2023Review
- SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers.Neurobiology of disease · 2022Article
- Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- The Role of Mitochondrial Genes in Neurodegenerative Disorders.Current neuropharmacology · 2022Review
- Article
- Characterization and Discovery of a Selective Small-Molecule Modulator of Mitochondrial Complex I Targeting a Unique Binding Site.Journal of medicinal chemistry · 2020Article
- The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer's Disease and Parkinson's Disease.Molecular neurobiology · 2020Review
- Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention.Antioxidants & redox signaling · 2020Review
- Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances.Molecular neurodegeneration · 2020Review
- Mitochondria in the signaling pathways that control longevity and health span.Ageing research reviews · 2019Review
- Assembly of 809 whole mitochondrial genomes with clinical, imaging, and fluid biomarker phenotyping.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Article
- A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease.Cell death & disease · 2018Review
- Review
- Mitochondria and Alzheimer's Disease: the Role of Mitochondrial Genetic Variation.Current genetic medicine reports · 2018Review
- Phylogenetic and population-based approaches to mitogenome variation do not support association with male infertility.Journal of human genetics · 2017Article
- Biocomplexity and Fractality in the Search of Biomarkers of Aging and Pathology: Focus on Mitochondrial DNA and Alzheimer's Disease.Aging and disease · 2017Article
- Mitochondrial Biology and Neurological Diseases.Current neuropharmacology · 2016Review
- Role of diffuse low-level heteroplasmy of mitochondrial DNA in Alzheimer's disease neurodegeneration.Frontiers in aging neuroscience · 2015Article
- Alzheimer's pathogenesis and its link to the mitochondrion.Oxidative medicine and cellular longevity · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 20 institutions in 4 countries.
Funding
Abstract
objectiveAlthough several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain.
methodsWe tested 138 mtDNA variants for association with AD in a powerful sample of 4,133 AD case patients and 1,602 matched controls from 3 Caucasian populations. Of the total population, 3,250 case patients and 1,221 elderly controls met the quality control criteria and were included in the analysis.
resultsIn the largest study to date, we failed to replicate the published findings. Meta-analysis of the available data showed no evidence of an association with AD.
conclusionThe current evidence linking common mtDNA variations with AD is not compelling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.