ArticleJournal of experimental botany2012
Low relative humidity triggers RNA-directed de novo DNA methylation and suppression of genes controlling stomatal development.
Article in Journal of experimental botany, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 130 citations in OpenAlex.
- SPEECHLESS duplication in grasses expands potential for environmental regulation of stomatal development.bioRxiv : the preprint server for biology · 2025Article
- Epigenetic Mechanisms Driving Adaptation in Tropical and Subtropical Plants: Insights and Future Directions.Plant, cell & environment · 2025Review
- Stomatal development in the changing climate.Development (Cambridge, England) · 2024Review
- Biochemical and Epigenetic Modulations under Drought: Remembering the Stress Tolerance Mechanism in Rice.Life (Basel, Switzerland) · 2023Article
- ZMP recruits and excludes Pol IV-mediated DNA methylation in a site-specific manner.Science advances · 2022Article
- Adapting to climate with limited genetic diversity: Nucleotide, DNA methylation and microbiome variation among populations of the social spider Stegodyphus dumicola.Molecular ecology · 2022Article
- Effect of DNA methylation, modified by 5-azaC, on ecophysiological responses of a clonal plant to changing climate.Scientific reports · 2022Article
- Induced Genetic Variations in Stomatal Density and Size of Rice Strongly Affects Water Use Efficiency and Responses to Drought Stresses.Frontiers in plant science · 2022Article
- The Dynamism of Transposon Methylation for Plant Development and Stress Adaptation.International journal of molecular sciences · 2021Review
- Article
- Dynamics of DNA Methylation and Its Functions in Plant Growth and Development.Frontiers in plant science · 2021Review
- RNA-directed DNA Methylation.PLoS genetics · 2020Article
- Machine learning analyses of methylation profiles uncovers tissue-specific gene expression patterns in wheat.The plant genome · 2020Article
- Agave angustifolia albino plantlets lose stomatal physiology function by changing the development of the stomatal complex due to a molecular disruption.Molecular genetics and genomics : MGG · 2020Article
- Identification, characterization, and functional prediction of circular RNAs in maize.Molecular genetics and genomics : MGG · 2020Article
- Greenhouse Spatial Effects Detected in the Barley (Frontiers in plant science · 2020Article
- Stomata and Sporophytes of the Model MossFrontiers in plant science · 2020Article
- Transgenerational Response to Nitrogen Deprivation inInternational journal of molecular sciences · 2019Article
- Water transport, perception, and response in plants.Journal of plant research · 2019Review
- The Tomato Genome Encodes SPCH, MUTE, and FAMA Candidates That Can Replace the Endogenous Functions of TheirFrontiers in plant science · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental cues influence the development of stomata on the leaf epidermis, and allow plants to exert plasticity in leaf stomatal abundance in response to the prevailing growing conditions. It is reported that Arabidopsis thaliana 'Landsberg erecta' plants grown under low relative humidity have a reduced stomatal index and that two genes in the stomatal development pathway, SPEECHLESS and FAMA, become de novo cytosine methylated and transcriptionally repressed. These environmentally-induced epigenetic responses were abolished in mutants lacking the capacity for de novo DNA methylation, for the maintenance of CG methylation, and in mutants for the production of short-interfering non-coding RNAs (siRNAs) in the RNA-directed DNA methylation pathway. Induction of methylation was quantitatively related to the induction of local siRNAs under low relative humidity. Our results indicate the involvement of both transcriptional and post-transcriptional gene suppression at these loci in response to environmental stress. Thus, in a physiologically important pathway, a targeted epigenetic response to a specific environmental stress is reported and several of its molecular, mechanistic components are described, providing a tractable platform for future epigenetics experiments. Our findings suggest epigenetic regulation of stomatal development that allows for anatomical and phenotypic plasticity, and may help to explain at least some of the plant's resilience to fluctuating relative humidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.