ArticleAmerican journal of epidemiology2012
Elevated risk of preeclampsia in pregnant women with depression: depression or antidepressants?
Article in American journal of epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03664128 (Pregnancy and Anxious Thoughts), which is not on this map. Cited by 45 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pregnancy and Anxious Thoughts: The Role of the Immune and Endocrine Systems
Who cites it
45 citing papers in PubMed, 5 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Depression and antidepressant use in pregnancy and adverse maternal and offspring outcomes: a systematic review and meta-analysis.Molecular psychiatry · 2025Pooled it
- Association of antidepressant use during pregnancy and pregnancy-induced hypertension: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Selective serotonin reuptake inhibitors and preeclampsia: A quality assessment and meta-analysis.Pregnancy hypertension · 2022Pooled it
- Treatment of depression, anxiety, and trauma-related disorders during the perinatal period: A systematic review.Clinical psychology review · 2018Pooled it
- Antenatal depressive symptoms and the risk of preeclampsia or operative deliveries: a meta-analysis.PloS one · 2015Pooled it
- Bupropion sustained release for pregnant smokers: a randomized, placebo-controlled trial.American journal of obstetrics and gynecology · 2017Trial
- Risks associated with antidepressants in patients with hypertension during pregnancy: a retrospective cohort study.Archives of gynecology and obstetrics · 2024Article
- Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Review
- Selective Serotonin Reuptake Inhibitor Use in Pregnancy and Protective Mechanisms in Preeclampsia.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Highlighting the Mechanistic Relationship Between Perinatal Depression and Preeclampsia: A Scoping Review.Women's health reports (New Rochelle, N.Y.) · 2022Article
- Preeclampsia and the longitudinal risk of hospitalization for depression at 28 years.Social psychiatry and psychiatric epidemiology · 2021Article
- Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Meta-Analysis of Pharmacotherapy.Psychiatric research and clinical practice · 2021Review
- Patterns of prenatal antidepressant exposure and risk of preeclampsia and postpartum haemorrhage.Paediatric and perinatal epidemiology · 2020Article
- Gestational Factors throughout Fetal Neurodevelopment: The Serotonin Link.International journal of molecular sciences · 2020Review
- Prenatal Antidepressant Use and Risk of Adverse Neonatal Outcomes.Pediatrics · 2020Article
- Prevalence, Correlates, and Outcomes of Co-Occurring Depression and Hypertensive Disorders of Pregnancy.Journal of women's health (2002) · 2019Article
- Use of antidepressants and anxiolytics in early pregnancy and the risk of preeclampsia and gestational hypertension: a prospective study.BMC pregnancy and childbirth · 2019Article
- Preeclampsia by maternal reasons for immigration: a population-based study.BMC pregnancy and childbirth · 2018Article
- Paternal use of antidepressants and offspring outcomes in Sweden: nationwide prospective cohort study.BMJ (Clinical research ed.) · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A previous study suggested an increased risk of preeclampsia among women treated with selective serotonin reuptake inhibitors (SSRIs). Using population-based health-care utilization databases from British Columbia (1997-2006), the authors conducted a study of 69,448 pregnancies in women with depression. They compared risk of preeclampsia in women using SSRIs, serotonin-norepinephrine reuptake inhibitors (SNRIs), or tricyclic antidepressants (TCAs) between gestational weeks 10 and 20 with risk in depressed women not using antidepressants. Among prepregnancy antidepressant users, the authors compared the risk in women who continued antidepressants between gestational weeks 10 and 24 with the risk in those who discontinued. Relative risks and 95% confidence intervals were estimated. The risk of preeclampsia in depressed women not treated with antidepressants (2.4%) was similar to that in women without depression (2.3%). Compared with women with untreated depression, women treated with SSRI, SNRI, and TCA monotherapy had adjusted relative risks of 1.22 (95% confidence interval (CI): 0.97, 1.54), 1.95 (95% CI: 1.25, 3.03), and 3.23 (95% CI: 1.87, 5.59), respectively. Within prepregnancy antidepressant users, the relative risk for preeclampsia among continuers compared with discontinuers was 1.32 (95% CI: 0.95, 1.84) for SSRI, 3.43 (95% CI: 1.77, 6.65) for SNRI, and 3.26 (95% CI: 1.04, 10.24) for TCA monotherapy. Study results suggest that women who use antidepressants during pregnancy, especially SNRIs and TCAs, have an elevated risk of preeclampsia. These associations may reflect drug effects or more severe depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.