Lgr5 expression is absent in human premalignant lesions of the stomach.

Tingting Wang, Khay Guan Yeoh, Manuel Salto-Tellez

Abstract readLetterComment

In one paragraph

Article in Gut, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

Distribution of LGR5+ cells and associated implications during the early stage of gastric tumorigenesis.PloS one · 2013
Trial
Colonic Stem Cells Expression of Lgr5 and CD133 Proteins as Predictive Markers in Colorectal Cancer among Egyptian Patients.Open access Macedonian journal of medical sciences · 2018
Article
Gastric Lgr5(+) stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice.Cell research · 2016
Article
Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway.Oncotarget · 2016
Article
EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016
Article
AXL is a key regulator of inherent and chemotherapy-induced invasion and predicts a poor clinical outcome in early-stage colon cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014
Article

4 · The record

Corrections and comments

Comment on
Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells.2012

5 · Who and what money

Authors and funding

3 authors.

Tingting Wang

Khay Guan Yeoh

Manuel Salto-Tellez

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBiomarkers, TumorIntercellular Signaling Peptides and ProteinsParietal Cells, GastricPeptidesPrecancerous ConditionsReceptors, G-Protein-CoupledStomach NeoplasmsBiomarkers, TumorIntercellular Signaling Peptides and ProteinsLgr5 protein, mousePeptidesReceptors, G-Protein-Coupledspasmolytic polypeptide

Identifiers

PMID22442165

DOI10.1136/gutjnl-2012-302372

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.