ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Caenorhabditis elegans flamingo cadherin fmi-1 regulates GABAergic neuronal development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 50 citations in OpenAlex.
- Article
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- Synaptic Cell Adhesion: A Functional Perspective.Advances in neurobiology · 2026Review
- Nervous system-wide analysis of allScience advances · 2025Article
- Synaptic Gα12/13 signaling establishes hippocampal PV inhibitory circuits.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Experience-dependent, sexually dimorphic synaptic connectivity defined by sex-specific cadherin expression.Science advances · 2024Article
- Essential Role of Latrophilin-1 Adhesion GPCR Nanoclusters in Inhibitory Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Experience-dependent, sexually dimorphic synaptic connectivity defined by sex-specific cadherin expression.bioRxiv : the preprint server for biology · 2024Article
- Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans.Nature communications · 2023Article
- The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.Cell reports · 2023Article
- Function of cell adhesion molecules in differentiation of ray sensory neurons in C. elegans.G3 (Bethesda, Md.) · 2023Article
- The Immunoglobulin Superfamily MembersJournal of developmental biology · 2022Article
- The regulatory landscape of neurite development inFrontiers in molecular neuroscience · 2022Review
- Mutations in the Spliceosome ComponentNeuroscience insights · 2022Article
- Age-dependent accumulation of tau aggregation inFrontiers in aging · 2022Article
- Ordered arrangement of dendrites within aeLife · 2018Article
- Cancer Cell Mechanics: Adhesion G Protein-coupled Receptors in Action?Frontiers in oncology · 2018Article
- Excitatory neurons sculpt GABAergic neuronal connectivity in theDevelopment (Cambridge, England) · 2017Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
In a genetic screen for regulators of synaptic morphology, we identified the single Caenorhabditis elegans flamingo-like cadherin fmi-1. The fmi-1 mutants exhibit defective axon pathfinding, reduced synapse number, aberrant synapse size and morphology, as well as an abnormal accumulation of synaptic vesicles at nonsynaptic regions. Although FMI-1 is primarily expressed in the nervous system, it is not expressed in the ventral D-type (VD) GABAergic motorneurons, which are defective in fmi-1 mutants. The axon and synaptic defects of VD neurons could be rescued when fmi-1 was expressed exclusively in non-VD neighboring neurons, suggesting a cell nonautonomous action of FMI-1. FMI-1 protein that lacked its intracellular domain still retained its ability to rescue the vesicle accumulation defects of GABAergic motorneurons, indicating that the extracellular domain was sufficient for this function of FMI-1 in GABAergic neuromuscular junction development. Mutations in cdh-4, a Fat-like cadherin, cause similar defects in GABAergic motorneurons. The cdh-4 is expressed by the VD neurons and seems to function in the same genetic pathway as fmi-1 to regulate GABAergic neuron development. Thus, fmi-1 and cdh-4 cadherins might act together to regulate synapse development and axon pathfinding.
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