ArticleClinical cancer research : an official journal of the American Association for Cancer Research2012
Disrupting the networks of cancer.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- CancerOmicsNet: a multi-omics network-based approach to anti-cancer drug profiling.Oncotarget · 2022Article
- The Systemic-Evolutionary Theory of the Origin of Cancer (SETOC): A New Interpretative Model of Cancer as a Complex Biological System.International journal of molecular sciences · 2019Review
- Targeting the tumour stroma to improve cancer therapy.Nature reviews. Clinical oncology · 2018Review
- Epigenetic control of macrophage polarization: implications for targeting tumor-associated macrophages.Oncotarget · 2018Review
- Ecological paradigms to understand the dynamics of metastasis.Cancer letters · 2016Review
- Can oncology recapitulate paleontology? Lessons from species extinctions.Nature reviews. Clinical oncology · 2015Review
- Evolution: Back to the future to understand and control prostate cancer.Asian journal of urology · 2014Article
- Niche inheritance: a cooperative pathway to enhance cancer cell fitness through ecosystem engineering.Journal of cellular biochemistry · 2014Article
- Beyond the androgen receptor: new approaches to treating metastatic prostate cancer. Report of the 2013 Prouts Neck Prostate Cancer Meeting.The Prostate · 2014Article
- The cancer diaspora: Metastasis beyond the seed and soil hypothesis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Review
- Laparoscopic total gastrectomy and gastric cancer genome architecture: lessons, cautions, and promises.Surgical endoscopy · 2013Article
- Integrative deep-sequencing analysis of cancer samples: discoveries and clinical challenges.The pharmacogenomics journal · 2013Article
- Complexity in cancer biology: is systems biology the answer?Cancer medicine · 2013Review
- Systems biology for molecular life sciences and its impact in biomedicine.Cellular and molecular life sciences : CMLS · 2013Review
- Human bone marrow mesenchymal stem cells induce collagen production and tongue cancer invasion.PloS one · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Ecosystems are interactive systems involving communities of species and their abiotic environment. Tumors are ecosystems in which cancer cells act as invasive species interacting with native host cell species in an established microenvironment within the larger host biosphere. At its heart, to study ecology is to study interconnectedness. In ecologic science, an ecologic network is a representation of the biotic interactions in an ecosystem in which species (nodes) are connected by pairwise interactions (links). Ecologic networks and signaling network models have been used to describe and compare the structures of ecosystems. It has been shown that disruption of ecologic networks through the loss of species or disruption of interactions between them can lead to the destruction of the ecosystem. Often, the destruction of a single node or link is not enough to disrupt the entire ecosystem. The more complex the network and its interactions, the more difficult it is to cause the extinction of a species, especially without leveraging other aspects of the ecosystem. Similarly, successful treatment of cancer with a single agent is rarely enough to cure a patient without strategically modifying the support systems conducive to survival of cancer. Cancer cells and the ecologic systems they reside in can be viewed as a series of nested networks. The most effective new paradigms for treatment will be developed through application of scaled network disruption.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.