Evidence map›Paper›PMID 22441898›Full record

ReviewJournal of surgical oncology2012

Molecular staging individualizing cancer management.

Alex Mejia, Stephanie Schulz, Terry Hyslop, David S Weinberg, Scott A Waldman

Abstract readReview
In one paragraph

Review in Journal of surgical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Single Nucleotide Polymorphisms in GenesRadiology and oncology · 2017
    Article
  6. Article
  7. Review
  8. Review
  9. SMAD4 and TS expression might predict the risk of recurrence after resection of colorectal liver metastases.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2015
    Article
  10. Article
  11. Immune cells: plastic players along colorectal cancer progression.Journal of cellular and molecular medicine · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alex MejiaDepartment of Pharmacology, Experimental Therapeutics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Stephanie Schulz
Terry Hyslop
David S Weinberg
Scott A Waldman
Thomas Jefferson University · USFox Chase Cancer Center · US

Funding

CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM008562 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI WALTER K KRAFT, Scott A. Waldman · 1995 to 2026
$10.2M
Guanylyl Cyclase C in Blood and Colorectal CancerR01CA095026 · NCI · THOMAS JEFFERSON UNIVERSITY · PI WALDMAN, SCOTT A · 2003 to 2008
$5.1M
GUANYLYL CYCLASE C AS A BIOMARKER FOR COLORECTAL CANCERR01CA075123 · NCI · THOMAS JEFFERSON UNIVERSITY · PI WALDMAN, SCOTT A. · 1998 to 2006
$5.1M
Training Program in Human InvestigationK30RR022299 · NCRR · THOMAS JEFFERSON UNIVERSITY · PI WALDMAN, SCOTT A · 2005 to 2009
$1.5M
Occult lymph node metastases and racial disparities in colon cancer outcomesRC1CA146033 · NCI · THOMAS JEFFERSON UNIVERSITY · PI WALDMAN, SCOTT A · 2009 to 2010
$997k
TRAINING PROGRAM IN HUMAN INVESTIGATIONK30HL004522 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI WALDMAN, SCOTT A. · 2000 to 2004
$964k
Nonlinear Models of mRNA Expression in Cancer by RT-PCRR33CA112147 · NCI · THOMAS JEFFERSON UNIVERSITY · PI HYSLOP, TERRY · 2007 to 2009
$666k
Nonlinear Models of mRNA Expression in Cancer by RT-PCRR21CA112147 · NCI · THOMAS JEFFERSON UNIVERSITY · PI HYSLOP, TERRY · 2005 to 2005
$140k
NCI NIH HHS CA112147NCI NIH HHS CA75123NCI NIH HHS CA95026NCI NIH HHS R01 CA075123NCI NIH HHS R01 CA095026NCI NIH HHS R21 CA112147NCI NIH HHS R33 CA112147NCI NIH HHS RC1 CA146033NCRR NIH HHS K30 RR022299NHLBI NIH HHS K30 HL004522NIGMS NIH HHS T32 GM008562
6 · The paper itself

Abstract

Although the most important prognostic and predictive marker in colorectal cancer is tumor cells in lymph nodes, approximately 30% of patients who are node-negative die from occult metastases. Molecular staging employing specific markers and sensitive detection technologies has emerged as a powerful platform to assess prognosis in node-negative colon cancer. Integrating molecular staging into algorithms that individualize patient management will require validation and the definition of relationships between occult tumor cells, prognosis, and responses to chemotherapy.

Indexed as

Reverse Transcriptase Polymerase Chain ReactionBiomarkers, TumorColonic NeoplasmsHumansLymphatic MetastasisLymph NodesNeoplasmsNeoplasm StagingPredictive Value of TestsPrognosisReceptors, EnterotoxinReceptors, Guanylate Cyclase-CoupledReceptors, PeptideRisk AssessmentRisk FactorsUnited StatesBiomarkers, TumorReceptors, EnterotoxinReceptors, Guanylate Cyclase-CoupledReceptors, Peptide

Identifiers

PMID22441898
PMCPMC3312802
OpenAlexW1972656465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.