ArticleEuropean archives of psychiatry and clinical neuroscience2012
Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients.
Article in European archives of psychiatry and clinical neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- What genes are differentially expressed in individuals with schizophrenia? A systematic review.Molecular psychiatry · 2022Pooled it
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- Transcriptional profile of pyramidal neurons in chronic schizophrenia reveals lamina-specific dysfunction of neuronal immunity.Molecular psychiatry · 2021Article
- Effects of haloperidol and clozapine on synapse-related gene expression in specific brain regions of male rats.European archives of psychiatry and clinical neuroscience · 2018Article
- The workflow from post-mortem human brain sampling to cell microdissection: a Brain Net Europe study.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Kraepelin revisited: schizophrenia from degeneration to failed regeneration.Molecular psychiatry · 2015Review
- [Neurobiology of schizophrenia: new findings from the structure to the molecules].Der Nervenarzt · 2015Review
- Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The impact of environmental factors in severe psychiatric disorders.Frontiers in neuroscience · 2014Review
- Transcriptome alterations of mitochondrial and coagulation function in schizophrenia by cortical sequencing analysis.BMC genomics · 2014Article
- Aripiprazole differentially regulates the expression of Gad67 and γ-aminobutyric acid transporters in rat brain.European archives of psychiatry and clinical neuroscience · 2013Article
- Schizophrenia: brain morphology and treatment aspects.European archives of psychiatry and clinical neuroscience · 2013Article
- Schizophrenia: from risk genes to outcome and comorbidity.European archives of psychiatry and clinical neuroscience · 2012Article
- A Latent Gaussian Copula Model for Mixed Data Analysis in Brain Imaging Genetics.IEEE/ACM transactions on computational biology and bioinformaticsArticle
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 5 countries.
Funding
Abstract
Inaccurate wiring and synaptic pathology appear to be major hallmarks of schizophrenia. A variety of gene products involved in synaptic neurotransmission and receptor signaling are differentially expressed in brains of schizophrenia patients. However, synaptic pathology may also develop by improper expression of intra- and extra-cellular structural elements weakening synaptic stability. Therefore, we have investigated transcription of these elements in the left superior temporal gyrus of 10 schizophrenia patients and 10 healthy controls by genome-wide microarrays (Illumina). Fourteen up-regulated and 22 downregulated genes encoding structural elements were chosen from the lists of differentially regulated genes for further qRT-PCR analysis. Almost all genes confirmed by this method were downregulated. Their gene products belonged to vesicle-associated proteins, that is, synaptotagmin 6 and syntaxin 12, to cytoskeletal proteins, like myosin 6, pleckstrin, or to proteins of the extracellular matrix, such as collagens, or laminin C3. Our results underline the pivotal roles of structural genes that control formation and stabilization of pre- and post-synaptic elements or influence axon guidance in schizophrenia. The glial origin of collagen or laminin highlights the close interrelationship between neurons and glial cells in establishment and maintenance of synaptic strength and plasticity. It is hypothesized that abnormal expression of these and related genes has a major impact on the pathophysiology of schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.