ArticleAmerican journal of clinical oncology2013
Incidence and prognostic significance of second primary cancers in renal cell carcinoma.
Article in American journal of clinical oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Risk of developing a second primary cancer following a renal cell carcinoma: a systematic review and meta-analysis.International urology and nephrology · 2026Pooled it
- Pleiotropy of cancer susceptibility variants on the risk of non-Hodgkin lymphoma: the PAGE consortium.PloS one · 2014Pooled it
- Article
- A nomogram for overall survival of second primary cancers following upper-tract urothelial carcinoma: a SEER population-based study.Translational cancer research · 2024Article
- Renal cell carcinoma and risk of second primary cancer: A Danish nationwide cohort study.Cancer medicine · 2024Article
- Pulmonary lesion after surgery for renal cancer: progression or new primary?World journal of urology · 2024Article
- A Rare Case of Concurrent Chromophobe Renal Cell Cancer with Lung Neuroendocrine Tumor: A Case Report and Literature Review.Annals of medicine and surgery (2012) · 2024Article
- NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma.Cancer biology & therapy · 2023Article
- PSMA PET/CT in Castration-Resistant Prostate Cancer: Myth or Reality?Journal of clinical medicine · 2023Review
- Letter to the editor regarding: comparison of survival outcomes in patients with metastatic papillary vs. clear-cell renal cell carcinoma: a propensity-score analysis.World journal of urology · 2021Article
- Second Primary Cancers After Kidney Cancers, and Kidney Cancers as Second Primary Cancers.European urology open science · 2021Article
- Clear Cell Papillary Renal Cell Carcinoma Shares Distinct Molecular Characteristics and may be Significantly Associated With Higher Risk of Developing Second Primary Malignancy.Pathology oncology research : POR · 2021Article
- A survival predicting model for patients with papillary renal cell carcinoma.Translational andrology and urology · 2020Article
- Clear cell renal carcinoma synchronous with dedifferentiated liposarcoma: a case report and review of the literature.Journal of medical case reports · 2020Review
- Article
- Synchronous invasive ductal carcinoma of the breast and clear cell renal carcinoma with rare presentation and behaviour: a case report with a literature review.Ecancermedicalscience · 2020Article
- The underlying molecular mechanism and potential drugs for treatment in papillary renal cell carcinoma: A study based on TCGA and Cmap datasets.Oncology reports · 2019Article
- Second Primary Cancer Risk among Kidney Cancer Patients in Korea: A Population-Based Cohort Study.Cancer research and treatment · 2018Article
- Quadruple primary urogenital cancers - A case report.International journal of surgery case reports · 2017Article
- Second primary malignancies in renal cortical neoplasms: an updated evaluation from a single institution.World journal of urology · 2016Article
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4 authors at 2 institutions in 1 country.
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Abstract
backgroundThe survival of patients with renal cell carcinoma (RCC) has improved in recent years. However, data on the risk of developing a second cancer after a diagnosis of RCC is limited. We used the data available in the Surveillance Epidemiology and End Results (SEER) database to estimate the risk of second metachronous primary cancers in patients diagnosed with RCC between 1973 and 2006. Furthermore, we also investigated the effect of the second primary cancers (SPCs) on the survival of RCC patients.
resultsA total of 3795 cases of SPCs were registered in the SEER between 1973 and 2006. The ratio of observed/expected number of SPCs in RCC was 1.18, which was significantly greater than expected. Solid tumors comprised 90% of all second malignancies in RCC patients, with the most second cancers reported in the prostate gland and the digestive and respiratory systems. The overall risk of second primaries was highest in patients aged over 30 years at the time of diagnosis. The site-specific risk of second cancers varied with the age at diagnosis, sex, race of the patient, size of the primary renal tumor, and history of radiation therapy. Patients with second primaries had a significantly longer overall survival than those without second malignancies. An interval of <1 year between the diagnosis of RCC and the second primary was the strongest predictor of poor overall survival in RCC patients with a second malignancy.
conclusionsPatients with RCC are at a significantly higher risk of developing a second malignancy, suggesting the need for careful surveillance for their early detection and management.
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